HCSGD entry for VKORC1
1. General information
| Official gene symbol | VKORC1 |
|---|---|
| Entrez ID | 79001 |
| Gene full name | vitamin K epoxide reductase complex, subunit 1 |
| Other gene symbols | EDTP308 IMAGE3455200 MST134 MST576 VKCFD2 VKOR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017144 | Drug metabolic process | IMP | biological_process |
| GO:0017187 | Peptidyl-glutamic acid carboxylation | TAS | biological_process |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0047057 | Vitamin-K-epoxide reductase (warfarin-sensitive) activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1247074617 | 0.2695084685 | 0.7206202195 | 0.9928540355 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1745711346 |
| GSE13712_SHEAR | Down | -0.3377699503 |
| GSE13712_STATIC | Down | -0.3049770865 |
| GSE19018 | Up | 1.9012612781 |
| GSE19899_A1 | Down | -0.1143159079 |
| GSE19899_A2 | Down | -0.0457629167 |
| PubMed_21979375_A1 | Up | 0.4293834395 |
| PubMed_21979375_A2 | Down | -0.3832222256 |
| GSE35957 | Down | -0.3777901813 |
| GSE36640 | Up | 0.6065935920 |
| GSE54402 | Down | -0.0857192115 |
| GSE9593 | Up | 0.5751367034 |
| GSE43922 | Down | -0.0144311521 |
| GSE24585 | Down | -0.2543823433 |
| GSE37065 | Up | 0.0017871774 |
| GSE28863_A1 | Up | 0.0046145446 |
| GSE28863_A2 | Up | 0.2183815363 |
| GSE28863_A3 | Up | 0.1204292329 |
| GSE28863_A4 | Down | -0.0594187351 |
| GSE48662 | Up | 0.4590323081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Menadione | DB00170 | NUTR00062 |
| Phenindione | DB00498 | APRD00166 |
| Warfarin | DB00682 | APRD00341 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133a-3p | MIMAT0000427 | MIRT007088 | Luciferase reporter assay | Functional MTI | 23154637 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022348 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-326 | MIMAT0000756 | MIRT043646 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044407 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051124 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
