HCSGD entry for KAT6A
1. General information
| Official gene symbol | KAT6A |
|---|---|
| Entrez ID | 7994 |
| Gene full name | K(lysine) acetyltransferase 6A |
| Other gene symbols | MOZ MYST3 RUNXBP2 ZC2HC6A ZNF220 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000786 | Nucleosome | IEA | cellular_component |
| GO:0003007 | Heart morphogenesis | IEA | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0004402 | Histone acetyltransferase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0006323 | DNA packaging | TAS | biological_process |
| GO:0006334 | Nucleosome assembly | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006473 | Protein acetylation | IDA | biological_process |
| GO:0008134 | Transcription factor binding | IDA | molecular_function |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0016407 | Acetyltransferase activity | IDA | molecular_function |
| GO:0016573 | Histone acetylation | IDA | biological_process |
| GO:0016605 | PML body | IDA | cellular_component |
| GO:0016747 | Transferase activity, transferring acyl groups other than amino-acyl groups | IEA | molecular_function |
| GO:0030099 | Myeloid cell differentiation | IDA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | IEA | biological_process |
| GO:0035162 | Embryonic hemopoiesis | IEA | biological_process |
| GO:0035909 | Aorta morphogenesis | IEA | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IEA | biological_process |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0060325 | Face morphogenesis | IEA | biological_process |
| GO:0070776 | MOZ/MORF histone acetyltransferase complex | IDA | cellular_component |
| GO:0090398 | Cellular senescence | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1713717222 | 0.5567291630 | 0.8136467640 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0514593332 |
| GSE13712_SHEAR | Up | 0.1028636856 |
| GSE13712_STATIC | Up | 0.0360604429 |
| GSE19018 | Down | -0.2171105843 |
| GSE19899_A1 | Up | 0.0709263934 |
| GSE19899_A2 | Down | -0.2376049899 |
| PubMed_21979375_A1 | Up | 0.1864828736 |
| PubMed_21979375_A2 | Up | 0.1701731791 |
| GSE35957 | Down | -0.3614893243 |
| GSE36640 | Down | -0.5636339072 |
| GSE54402 | Up | 0.2350414312 |
| GSE9593 | Down | -0.1848985077 |
| GSE43922 | Down | -0.0082296008 |
| GSE24585 | Up | 0.0629629530 |
| GSE37065 | Up | 0.0425458800 |
| GSE28863_A1 | Up | 1.1455290154 |
| GSE28863_A2 | Up | 1.0970836631 |
| GSE28863_A3 | Down | -0.2560847092 |
| GSE28863_A4 | Up | 0.0682127064 |
| GSE48662 | Down | -0.0399289079 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-425-5p | MIMAT0003393 | MIRT016673 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031066 | Microarray | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037040 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038467 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041326 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25772242 | MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway |
| 25772242 | In this study, we investigate the role of MOZ in cellular senescence and show that MOZ is a potent inhibitor of senescence via the INK4A-ARF pathway |
| 25772242 | Importantly, senescence resulting from the absence of MOZ was not accompanied by DNA damage, suggesting that MOZ acts independently of the DNA damage response |
| 25772242 | We show that MOZ is required to maintain normal levels of histone 3 lysine 9 (H3K9) and H3K27 acetylation at the transcriptional start sites of at least four genes, Cdc6, Ezh2, E2f2 and Melk, and normal mRNA levels of these genes |
| 25772242 | Using chromatin immunoprecipitation, we show that MOZ occupies the Cdc6, Ezh2 and Melk loci, thereby providing a direct link between MOZ, H3K9 and H3K27 acetylation, and normal transcriptional levels at these loci |
| 25772242 | This work establishes that MOZ is an upstream inhibitor of the INK4A-ARF pathway, and suggests that inhibiting MOZ may be one way to induce senescence in proliferative tumour cells |
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