HCSGD entry for CTC1
1. General information
| Official gene symbol | CTC1 |
|---|---|
| Entrez ID | 80169 |
| Gene full name | CTS telomere maintenance complex component 1 |
| Other gene symbols | AAF-132 AAF132 C17orf68 CRMCC tmp494178 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | IMP | biological_process |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0003697 | Single-stranded DNA binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0010389 | Regulation of G2/M transition of mitotic cell cycle | IEA | biological_process |
| GO:0010833 | Telomere maintenance via telomere lengthening | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0045740 | Positive regulation of DNA replication | ISS | biological_process |
| GO:0048146 | Positive regulation of fibroblast proliferation | IEA | biological_process |
| GO:0048536 | Spleen development | IEA | biological_process |
| GO:0048538 | Thymus development | IEA | biological_process |
| GO:0048539 | Bone marrow development | IEA | biological_process |
| GO:0070188 | Stn1-Ten1 complex | ISS | cellular_component |
| GO:0071425 | Hematopoietic stem cell proliferation | IEA | biological_process |
| GO:0090399 | Replicative senescence | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1227121766 | 0.9693198549 | 0.7164122395 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0724735254 |
| GSE13712_SHEAR | Up | 0.0951837330 |
| GSE13712_STATIC | Up | 0.1554237180 |
| GSE19018 | Up | 0.1043629567 |
| GSE19899_A1 | Down | -0.0654734137 |
| GSE19899_A2 | Up | 0.3570949568 |
| PubMed_21979375_A1 | Up | 0.7326195845 |
| PubMed_21979375_A2 | Up | 0.0680394558 |
| GSE35957 | Up | 0.0616126532 |
| GSE36640 | Up | 0.1773524913 |
| GSE54402 | Up | 0.0712040034 |
| GSE9593 | Up | 0.0198833226 |
| GSE43922 | Up | 0.3383519688 |
| GSE24585 | Up | 0.4559399206 |
| GSE37065 | Up | 0.0776936913 |
| GSE28863_A1 | Up | 0.1583407164 |
| GSE28863_A2 | Down | -0.1382179566 |
| GSE28863_A3 | Up | 0.0833352509 |
| GSE28863_A4 | Up | 0.0753584300 |
| GSE48662 | Down | -0.0369012505 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038559 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-1-3p | MIMAT0004553 | MIRT038679 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038786 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039186 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039400 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039476 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040272 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040539 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181d-5p | MIMAT0002821 | MIRT041173 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043267 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT044235 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048592 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048685 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048774 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048968 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050102 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050328 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051436 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3615 | MIMAT0017994 | MIRT052856 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
