HCSGD entry for CAPN3

1. General information

Official gene symbolCAPN3
Entrez ID825
Gene full namecalpain 3, (p94)
Other gene symbolsCANP3 CANPL3 LGMD2 LGMD2A nCL-1 p94
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001896AutolysisIEAbiological_process
GO:0003824Catalytic activityIDAmolecular_function
GO:0004198Calcium-dependent cysteine-type endopeptidase activityIEA ISS TASmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005509Calcium ion bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEA TAScellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEA ISScellular_component
GO:0005886Plasma membraneIEA ISScellular_component
GO:0006461Protein complex assemblyIEA ISSbiological_process
GO:0006508ProteolysisIDA IEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008234Cysteine-type peptidase activityTASmolecular_function
GO:0008307Structural constituent of muscleIEA ISSmolecular_function
GO:0014718Positive regulation of satellite cell activation involved in skeletal muscle regenerationIEA ISSbiological_process
GO:0014850Response to muscle activityISSbiological_process
GO:0030016MyofibrilISScellular_component
GO:0030018Z discISScellular_component
GO:0030239Myofibril assemblyISS TASbiological_process
GO:0030315T-tubuleISScellular_component
GO:0031402Sodium ion bindingIEA ISSmolecular_function
GO:0031432Titin bindingIPImolecular_function
GO:0032947Protein complex scaffoldIEA ISSmolecular_function
GO:0033234Negative regulation of protein sumoylationIDAbiological_process
GO:0043066Negative regulation of apoptotic processIEA IMPbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIEA IMPbiological_process
GO:0043234Protein complexIEA ISScellular_component
GO:0045214Sarcomere organizationIEA ISSbiological_process
GO:0045661Regulation of myoblast differentiationIEAbiological_process
GO:0045862Positive regulation of proteolysisIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEA ISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEA IMPbiological_process
GO:0046716Muscle cell cellular homeostasisTASbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEA IMPbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIEA ISSbiological_process
GO:0051592Response to calcium ionISSbiological_process
GO:0055103Ligase regulator activityIDAmolecular_function
GO:0061061Muscle structure developmentISSbiological_process
GO:0070315G1 to G0 transition involved in cell differentiationIEAbiological_process
GO:0071277Cellular response to calcium ionIEA ISSbiological_process
GO:0071472Cellular response to salt stressIEA ISSbiological_process
GO:0072657Protein localization to membraneIEA ISSbiological_process
GO:0097264Self proteolysisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21296347780.97190383340.88960668151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4108457615
GSE13712_SHEARDown-0.0326780229
GSE13712_STATICUp0.1870071780
GSE19018Down-0.0414368126
GSE19899_A1Up0.1045878953
GSE19899_A2Up0.3030775356
PubMed_21979375_A1Up0.5185980030
PubMed_21979375_A2Up0.1831203650
GSE35957Up0.0041645790
GSE36640Up0.1232457628
GSE54402Up0.0520197252
GSE9593Down-0.0424970824
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1795245840

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.