HCSGD entry for CDC7
1. General information
| Official gene symbol | CDC7 |
|---|---|
| Entrez ID | 8317 |
| Gene full name | cell division cycle 7 |
| Other gene symbols | CDC7L1 HsCDC7 Hsk1 huCDC7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0016301 | Kinase activity | IDA | molecular_function |
| GO:0044770 | Cell cycle phase transition | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051301 | Cell division | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9716272254 | 0.0002795486 | 0.9999902473 | 0.0307866109 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0905062178 |
| GSE13712_SHEAR | Up | 0.0536132226 |
| GSE13712_STATIC | Up | 0.4347793033 |
| GSE19018 | Down | -1.4339893846 |
| GSE19899_A1 | Down | -0.4438824836 |
| GSE19899_A2 | Down | -3.6138477013 |
| PubMed_21979375_A1 | Down | -1.4265533682 |
| PubMed_21979375_A2 | Down | -2.9255980505 |
| GSE35957 | Down | -2.7202447489 |
| GSE36640 | Down | -4.2828892038 |
| GSE54402 | Down | -0.4541970153 |
| GSE9593 | Down | -2.0454464151 |
| GSE43922 | Down | -0.4554331271 |
| GSE24585 | Down | -0.0031340769 |
| GSE37065 | Down | -0.1484736061 |
| GSE28863_A1 | Up | 0.1274645598 |
| GSE28863_A2 | Up | 0.7648466993 |
| GSE28863_A3 | Down | -0.1265888865 |
| GSE28863_A4 | Up | 0.0176663591 |
| GSE48662 | Down | -1.0706235929 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004845 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;Microarray;Other | Functional MTI | 19074876 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024755 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027255 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039691 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052381 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15236317 | The candidate genes PRKCL2 and GTF2B, within SRO2, and TGFBR3, CDC7, and EVI5, in a broad region encompassing SRO3, were screened in 1p22-linked melanoma kindreds, but no coding mutations were detected |
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