HCSGD entry for BRIP1
1. General information
| Official gene symbol | BRIP1 |
|---|---|
| Entrez ID | 83990 |
| Gene full name | BRCA1 interacting protein C-terminal helicase 1 |
| Other gene symbols | BACH1 FANCJ OF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | NAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA NAS | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA NAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | NAS | biological_process |
| GO:0006302 | Double-strand break repair | NAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0016817 | Hydrolase activity, acting on acid anhydrides | IEA | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0032508 | DNA duplex unwinding | NAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9557751567 | 0.0000407127 | 0.9999902473 | 0.0109660000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.4887760685 |
| GSE13712_SHEAR | Down | -0.0177672355 |
| GSE13712_STATIC | Up | 0.2651935398 |
| GSE19018 | Down | -0.6995281732 |
| GSE19899_A1 | Down | -0.9808503331 |
| GSE19899_A2 | Down | -4.5370520309 |
| PubMed_21979375_A1 | Down | -2.5047800651 |
| PubMed_21979375_A2 | Down | -3.9828470756 |
| GSE35957 | Down | -2.5485445637 |
| GSE36640 | Down | -3.8407933332 |
| GSE54402 | Down | -1.6802423407 |
| GSE9593 | Down | -1.1211776839 |
| GSE43922 | Down | -2.2455470053 |
| GSE24585 | Up | 0.6644239326 |
| GSE37065 | Up | 0.2848305331 |
| GSE28863_A1 | Down | -0.2120313515 |
| GSE28863_A2 | Up | 0.2611163738 |
| GSE28863_A3 | Down | -0.2072692211 |
| GSE28863_A4 | Up | 0.0832663286 |
| GSE48662 | Down | -0.6529528395 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024519 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026770 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-378a-5p | MIMAT0000731 | MIRT043978 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-182-5p | MIMAT0000259 | MIRT047176 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | 1 | hsa-miR-155 | 17881434 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
