HCSGD entry for TP63

1. General information

Official gene symbolTP63
Entrez ID8626
Gene full nametumor protein p63
Other gene symbolsAIS B(p51A) B(p51B) EEC3 KET LMS NBP OFC8 RHS SHFM4 TP53CP TP53L TP73L p40 p51 p53CP p63 p73H p73L
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0000785ChromatinIBAcellular_component
GO:0000790Nuclear chromatinIDAcellular_component
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001501Skeletal system developmentIEAbiological_process
GO:0001736Establishment of planar polarityIEAbiological_process
GO:0002039P53 bindingIBAmolecular_function
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0002064Epithelial cell developmentIEAbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0003682Chromatin bindingIBA IDAmolecular_function
GO:0003684Damaged DNA bindingIBAmolecular_function
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIBA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEA NAScellular_component
GO:0005654NucleoplasmIDAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIBAcellular_component
GO:0006338Chromatin remodelingIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processIEA TASbiological_process
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIBAbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0007499Ectoderm and mesoderm interactionIEAbiological_process
GO:0007569Cell agingIEAbiological_process
GO:0009954Proximal/distal pattern formationIEAbiological_process
GO:0010165Response to X-rayIBAbiological_process
GO:0010259Multicellular organismal agingIEAbiological_process
GO:0010332Response to gamma radiationIBAbiological_process
GO:0010481Epidermal cell divisionIEAbiological_process
GO:0030216Keratinocyte differentiationIEAbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0030425DendriteIBAcellular_component
GO:0030859Polarized epithelial cell differentiationIEAbiological_process
GO:0031069Hair follicle morphogenesisIEAbiological_process
GO:0031571Mitotic G1 DNA damage checkpointIBAbiological_process
GO:0034644Cellular response to UVIBAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIBAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043523Regulation of neuron apoptotic processIBAbiological_process
GO:0043565Sequence-specific DNA bindingIBAmolecular_function
GO:0043616Keratinocyte proliferationIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045617Negative regulation of keratinocyte differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA NASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048485Sympathetic nervous system developmentIEAbiological_process
GO:0048745Smooth muscle tissue developmentIEAbiological_process
GO:0048807Female genitalia morphogenesisIEAbiological_process
GO:0051289Protein homotetramerizationIPIbiological_process
GO:0051402Neuron apoptotic processIEAbiological_process
GO:0060157Urinary bladder developmentIEAbiological_process
GO:0060197Cloacal septationIEAbiological_process
GO:0060513Prostatic bud formationIEAbiological_process
GO:0060529Squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentIEAbiological_process
GO:2000271Positive regulation of fibroblast apoptotic processIDAbiological_process
GO:2000381Negative regulation of mesoderm developmentIEAbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68454432580.88646612590.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0080934248
GSE13712_SHEARDown-0.0706726734
GSE13712_STATICUp0.0393696870
GSE19018Up0.1133003846
GSE19899_A1Up0.0883226259
GSE19899_A2Up0.0346628163
PubMed_21979375_A1Up0.0720409341
PubMed_21979375_A2Up0.0663307411
GSE35957Down-0.0745251497
GSE36640Up0.0272806577
GSE54402Down-0.0073402835
GSE9593Down-0.1031158760
GSE43922Up0.0153269426
GSE24585Up0.0660069715
GSE37065Down-0.2309125243
GSE28863_A1Up0.0698605970
GSE28863_A2Up0.2874554939
GSE28863_A3Up0.1433464549
GSE28863_A4Down-0.0099841342
GSE48662Up0.0907558721

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-203aMIMAT0000264MIRT004248Luciferase reporter assayFunctional MTI18311128
hsa-miR-203aMIMAT0000264MIRT004248qRT-PCR//Western blot//Luciferase reporter assayFunctional MTI18483491
hsa-miR-92a-3pMIMAT0000092MIRT004281Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19608627
hsa-miR-21-5pMIMAT0000076MIRT005329Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI18829576
hsa-miR-124-3pMIMAT0000422MIRT022864MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-203aMIMAT00002641hsa-miR-20318483491
hsa-miR-302b-3pMIMAT00007151hsa-miR-302b{Western blot}{overexpression by miRNA precursor transfection}19342891
hsa-miR-302b-3pMIMAT00007152hsa-miR-302b{Western blot}{overexpression by miRNA precursor transfection}19342891
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21703418The TP63 gene, a TP53 homologue, encodes for two main isoforms by different promoters: one retains (TA) and the other lacks (DeltaN) the transactivation domain
17609671A new mutation in TP63 is associated with age-related pathology
17609671TP63 (also known as TP73L) mutations have been identified in several such syndromes characterized by autosomal dominant transmission and various combinations of ectodermal dysplasia, limb malformations and orofacial clefting
17609671We report on a family with four affected adult females presenting with Rapp-Hodgkin syndrome (RHS), an autosomal dominant clinical entity that associates anhidrotic ectodermal dysplasia with cleft lip and palate
17609671Features between RHS and EEC syndrome (ectrodactyly, ectodermal dysplasia and cleft lip/palate) have led to the recent identification of mutations in the TP63 gene, located on 3q27, in this condition
17609671Our patients present typical clinical features of RHS, but also ophthalmic anomalies such as corneal dystrophy and premature menopause (around 30 years)
17609671The latter findings have never been reported in this condition, and could be secondary to a new TP63 deletion that has been identified in this family
80500302) against terminin, we identified a 63 kDa polypeptide (Tp63) in the detergent-insoluble fraction of human brain proteins, which can be identified by either one- or two-dimensional electrophoresis
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