HCSGD entry for MBTPS1
1. General information
| Official gene symbol | MBTPS1 |
|---|---|
| Entrez ID | 8720 |
| Gene full name | membrane-bound transcription factor peptidase, site 1 |
| Other gene symbols | PCSK8 S1P SKI-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0004252 | Serine-type endopeptidase activity | IBA IEA | molecular_function |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IBA | cellular_component |
| GO:0005795 | Golgi stack | IEA | cellular_component |
| GO:0006508 | Proteolysis | IBA IEA | biological_process |
| GO:0006629 | Lipid metabolic process | IBA IEA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0042990 | Regulation of transcription factor import into nucleus | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2438587136 | 0.4144499905 | 0.9320535134 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1139779016 |
| GSE13712_SHEAR | Down | -0.3419333838 |
| GSE13712_STATIC | Down | -0.1748071818 |
| GSE19018 | Up | 0.1801374310 |
| GSE19899_A1 | Down | -0.2026839787 |
| GSE19899_A2 | Up | 0.2575835117 |
| PubMed_21979375_A1 | Down | -0.2052065334 |
| PubMed_21979375_A2 | Down | -0.0485686105 |
| GSE35957 | Up | 0.2069055563 |
| GSE36640 | Up | 0.6351374372 |
| GSE54402 | Down | -0.2619599318 |
| GSE9593 | Up | 0.6017175455 |
| GSE43922 | Down | -0.0133543971 |
| GSE24585 | Up | 0.1384179489 |
| GSE37065 | Down | -0.1821200487 |
| GSE28863_A1 | Up | 0.5540488989 |
| GSE28863_A2 | Up | 0.4849394461 |
| GSE28863_A3 | Down | -0.5127027339 |
| GSE28863_A4 | Up | 0.0598001759 |
| GSE48662 | Up | 0.0964911631 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-769-3p | MIMAT0003887 | MIRT039121 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041290 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051782 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26857736 | Human CCR7(low)CD45RA(high) effector memory CD8(+) T cells (terminally differentiated TEMRA) are reportedly a functionally compromised population with characteristics of cellular senescence when examined ex vivo Although their frequencies are increased in elderly subjects in association with declined immune competence, however, it remains unclear whether their impaired functions can be reversed so that they contribute to immune responses in vivo Here, I show that, in contrast to TCR stimulation, stimulation of TEMRA with IL-15 induced a unique transcriptional signature, promoted IFN-gamma production and cell cycle entry, and reduced chemotaxis toward sphingosine-1-phosphate (S1P) |
| 26857736 | This accumulation was impaired by S1P receptor 1 over-expression |
| 26082434 | Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation |
| 26082434 | Docking predictions and mutational analyses revealed that binding occurred between a hydroxyl group (C'3-OH) in S1P and Asp(684) in hTERT |
| 26082434 | Thus, our data suggest that S1P binding to hTERT allosterically mimicks phosphorylation, promoting telomerase stability and hence telomere maintenance, cell proliferation, and tumor growth |
| 22005951 | The bioactive sphingolipids including, ceramide, sphingosine, and sphingosine-1-phosphate (S1P) have important roles in several types of signaling and regulation of many cellular processes including cell proliferation, apoptosis, senescence, angiogenesis, and transformation |
| 22005951 | Ceramide mediates numerous cell-stress responses, such as induction of apoptosis and cell senescence, whereas S1P plays pivotal roles in cell survival, migration, and inflammation |
| 22005951 | Importantly, these sphingolipids are metabolically related through actions of enzymes including ceramidases, ceramide synthases, sphingosine kinases, and S1P phosphatases thereby forming a network of metabolically interrelated bioactive lipid mediators whose importance in normal cellular function and diseases is gaining appreciation |
| 18765664 | In this study, we investigated the signaling and functions of sphingosine 1-phosphate (S1P), a serum-borne bioactive sphingolipid, in ECs of different in vitro ages |
| 18765664 | These results indicate that the impairment of function in senescent ECs in culture is mediated by an increase in S1P signaling through S1P(2)-mediated activation of the lipid phosphatase PTEN |
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