HCSGD entry for KAT2B

1. General information

Official gene symbolKAT2B
Entrez ID8850
Gene full nameK(lysine) acetyltransferase 2B
Other gene symbolsCAF P P/CAF PCAF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000125PCAF complexNAScellular_component
GO:0000776KinetochoreIEAcellular_component
GO:0003712Transcription cofactor activityIPImolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0004402Histone acetyltransferase activityIEAmolecular_function
GO:0004468Lysine N-acetyltransferase activityIDA ISSmolecular_function
GO:0004861Cyclin-dependent protein serine/threonine kinase inhibitor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005671Ada2/Gcn5/Ada3 transcription activator complexIDAcellular_component
GO:0006338Chromatin remodelingIDA NASbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006473Protein acetylationTASbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010835Regulation of protein ADP-ribosylationIDAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016407Acetyltransferase activityIDAmolecular_function
GO:0018076N-terminal peptidyl-lysine acetylationIDAbiological_process
GO:0018393Internal peptidyl-lysine acetylationIDAbiological_process
GO:0018394Peptidyl-lysine acetylationIDAbiological_process
GO:0019901Protein kinase bindingISSmolecular_function
GO:0031672A bandIEAcellular_component
GO:0031674I bandIEAcellular_component
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032869Cellular response to insulin stimulusIDAbiological_process
GO:0042641ActomyosinIEAcellular_component
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043966Histone H3 acetylationIDAbiological_process
GO:0045736Negative regulation of cyclin-dependent protein serine/threonine kinase activityIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30742308420.01150810760.99999024730.2125289510

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5429819886
GSE13712_SHEARDown-0.1654872230
GSE13712_STATICDown-0.5744163933
GSE19018Down-0.8119129592
GSE19899_A1Down-0.2538886805
GSE19899_A2Down-1.1094331397
PubMed_21979375_A1Up1.0774153910
PubMed_21979375_A2Down-0.2231628722
GSE35957Up0.6438003696
GSE36640Up0.9334175465
GSE54402Down-0.9611812666
GSE9593Up0.3424182658
GSE43922Down-0.0887963194
GSE24585Up1.0681382934
GSE37065Up0.1880955248
GSE28863_A1Down-0.2380388098
GSE28863_A2Up0.0132291253
GSE28863_A3Down-0.7924134238
GSE28863_A4Down-0.3506895522
GSE48662Down-0.3293935979

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1795607CHEMBL55009Q92831
CHEMBL521965CHEMBL55009Q92831
CHEMBL1795800CHEMBL55009Q92831
CHEMBL461475CHEMBL55009Q92831
CHEMBL1795620CHEMBL55009Q92831
CHEMBL99137CHEMBL55009Q92831
CHEMBL466866CHEMBL55009Q92831
CHEMBL487295CHEMBL55009Q92831
CHEMBL102387CHEMBL55009Q92831
CHEMBL1795612CHEMBL55009Q92831
CHEMBL1795799CHEMBL55009Q92831
CHEMBL1795622CHEMBL55009Q92831
CHEMBL1795796CHEMBL55009Q92831
CHEMBL1795609CHEMBL55009Q92831
CHEMBL572736CHEMBL55009Q92831
CHEMBL316658CHEMBL55009Q92831
CHEMBL1795604CHEMBL55009Q92831
CHEMBL1795605CHEMBL55009Q92831
CHEMBL510872CHEMBL55009Q92831
CHEMBL509992CHEMBL55009Q92831
CHEMBL442599CHEMBL55009Q92831
CHEMBL489115CHEMBL55009Q92831
CHEMBL1795611CHEMBL55009Q92831
CHEMBL573028CHEMBL55009Q92831
CHEMBL1795605CHEMBL55009Q92831
CHEMBL1795624CHEMBL55009Q92831
CHEMBL1795610CHEMBL55009Q92831
CHEMBL1795614CHEMBL55009Q92831
CHEMBL447612CHEMBL55009Q92831
CHEMBL99137CHEMBL55009Q92831
CHEMBL1795619CHEMBL55009Q92831
CHEMBL1795606CHEMBL55009Q92831
CHEMBL1795609CHEMBL55009Q92831
CHEMBL1795615CHEMBL55009Q92831
CHEMBL106011CHEMBL55009Q92831
CHEMBL1795616CHEMBL55009Q92831
CHEMBL101422CHEMBL55009Q92831
CHEMBL1795606CHEMBL55009Q92831
CHEMBL98663CHEMBL55009Q92831
CHEMBL1795623CHEMBL55009Q92831
CHEMBL1795611CHEMBL55009Q92831
CHEMBL510900CHEMBL55009Q92831
CHEMBL1795799CHEMBL55009Q92831
CHEMBL490684CHEMBL55009Q92831
CHEMBL106011CHEMBL55009Q92831
CHEMBL95284CHEMBL55009Q92831
CHEMBL509992CHEMBL55009Q92831
CHEMBL318367CHEMBL55009Q92831
CHEMBL455368CHEMBL55009Q92831
CHEMBL461475CHEMBL55009Q92831
CHEMBL489116CHEMBL55009Q92831
CHEMBL447612CHEMBL55009Q92831
CHEMBL1795618CHEMBL55009Q92831
CHEMBL443133CHEMBL55009Q92831
CHEMBL487269CHEMBL55008Q92831
CHEMBL499919CHEMBL55008Q92831
CHEMBL487498CHEMBL55008Q92831
CHEMBL1213327CHEMBL55008Q92831
CHEMBL489495CHEMBL55008Q92831
CHEMBL491092CHEMBL55008Q92831
CHEMBL501034CHEMBL55008Q92831
CHEMBL99594CHEMBL55008Q92831
CHEMBL443951CHEMBL55008Q92831
CHEMBL489102CHEMBL55008Q92831
CHEMBL316658CHEMBL55008Q92831
CHEMBL474276CHEMBL55008Q92831
CHEMBL502489CHEMBL55008Q92831
CHEMBL489494CHEMBL55008Q92831
CHEMBL489101CHEMBL55008Q92831
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  • Drugs

Name

Drug

Accession number

Coenzyme ADB01992 EXPT00991
(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONEDB08186 -
N-(3-AMINOPROPYL)-2-NITROBENZENAMINEDB08291 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT004327Western blot//Luciferase reporter assayFunctional MTI18728182
hsa-miR-181b-5pMIMAT0000257MIRT004328Western blot//Luciferase reporter assayFunctional MTI18728182
hsa-miR-25-3pMIMAT0000081MIRT004329Western blot//Luciferase reporter assayFunctional MTI18728182
hsa-miR-32-5pMIMAT0000090MIRT004330Western blot//Luciferase reporter assayFunctional MTI18728182
hsa-miR-92a-3pMIMAT0000092MIRT004331Western blot//Luciferase reporter assayNon-Functional MTI18728182
hsa-miR-93-5pMIMAT0000093MIRT004332Western blot//Luciferase reporter assayFunctional MTI18728182
hsa-miR-106b-5pMIMAT0000680MIRT004333Western blot//Luciferase reporter assayFunctional MTI18728182
hsa-miR-106b-5pMIMAT0000680MIRT004333MicroarrayFunctional MTI (Weak)17242205
hsa-miR-19a-3pMIMAT0000073MIRT004334Western blot//Luciferase reporter assayNon-Functional MTI18728182
hsa-miR-19b-3pMIMAT0000074MIRT004335Western blot//Luciferase reporter assayNon-Functional MTI18728182
hsa-miR-215-5pMIMAT0000272MIRT024568MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026230MicroarrayFunctional MTI (Weak)19074876
hsa-miR-26b-5pMIMAT0000083MIRT029198MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27081703Suppression of MARCKS resulted in the loss of CAF features, and diminished role of CAFs in supporting tumor cell growth in 3D organotypic cultures and in murine xenograft model
27081703Mechanistically, we found that MARCKS maintained CAF activation through suppression of cellular senescence and activation of the AKT/Twist1 signaling
24458358These observations were paralleled by a downregulation of the GCN5-related N-acetyltransferases (GNAT) p300/CBP-associated factor and its isoform 5-alpha general control of amino acid synthesis (GCN5a), determining a relative decrease in total HAT activity
23953057In this study, we found that cancer-associated fibroblasts (CAF) but not normal fibroblasts (NF) secrete high level of IL-6 with activated STAT3 and appear senescent at early passages in culture or in cervical cancer tissues infected with high-risk HPV, and that treatment of NF with recombinant IL-6 or CAF conditioned medium (CM) induces activation of STAT3 and cellular senescence
23953057The tumour growth of cervical cancer cells reconstituted with CAF or NF is largely affected by inhibition of fibroblast senescence with STAT3 inhibitor or with IL-6 antibody treatment
16516887Relocalization occurs concomitantly with interaction with a subset of nuclear proteins, including PCNA, p53 and several regulators of acetylation such as the p300/CBP and PCAF histone acetyltransferases (HATs), as well as the histone deacetylases HDAC1 and hSir2
11707903Cross-linking experiments indicated that NF-Y may interact with proteins such as GCN5 and P/CAF
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