HCSGD entry for CDK5R1

1. General information

Official gene symbolCDK5R1
Entrez ID8851
Gene full namecyclin-dependent kinase 5, regulatory subunit 1 (p35)
Other gene symbolsCDK5P35 CDK5R NCK5A p23 p25 p35 p35nck5a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityTASbiological_process
GO:0001764Neuron migrationISSbiological_process
GO:0004672Protein kinase activityTASmolecular_function
GO:0004693Cyclin-dependent protein serine/threonine kinase activityIEAmolecular_function
GO:0005509Calcium ion bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007158Neuron cell-cell adhesionISSbiological_process
GO:0007213G-protein coupled acetylcholine receptor signaling pathwayISSbiological_process
GO:0007411Axon guidanceISS TASbiological_process
GO:0007413Axonal fasciculationISSbiological_process
GO:0007420Brain developmentISS NASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0009790Embryo developmentISSbiological_process
GO:0014069Postsynaptic densityISScellular_component
GO:0016020MembraneISScellular_component
GO:0016301Kinase activityISSmolecular_function
GO:0016533Cyclin-dependent protein kinase 5 holoenzyme complexIEAcellular_component
GO:0016534Cyclin-dependent protein kinase 5 activator activityIEAmolecular_function
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0021549Cerebellum developmentIEAbiological_process
GO:0021722Superior olivary nucleus maturationIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021819Layer formation in cerebral cortexIEAbiological_process
GO:0030182Neuron differentiationISSbiological_process
GO:0030424AxonISScellular_component
GO:0030425DendriteISScellular_component
GO:0030426Growth coneISScellular_component
GO:0030517Negative regulation of axon extensionIEAbiological_process
GO:0031175Neuron projection developmentISSbiological_process
GO:0031594Neuromuscular junctionISScellular_component
GO:0032956Regulation of actin cytoskeleton organizationIEAbiological_process
GO:0033136Serine phosphorylation of STAT3 proteinIEAbiological_process
GO:0035235Ionotropic glutamate receptor signaling pathwayISSbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0043197Dendritic spineISScellular_component
GO:0043292Contractile fiberISScellular_component
GO:0043525Positive regulation of neuron apoptotic processISSbiological_process
GO:0043539Protein serine/threonine kinase activator activityIDA ISSmolecular_function
GO:0045296Cadherin bindingISSmolecular_function
GO:0045664Regulation of neuron differentiationNASbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0046875Ephrin receptor bindingIEAmolecular_function
GO:0048013Ephrin receptor signaling pathwayISSbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0061001Regulation of dendritic spine morphogenesisISSbiological_process
GO:0070507Regulation of microtubule cytoskeleton organizationIEAbiological_process
GO:0090314Positive regulation of protein targeting to membraneIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11541983970.69063108920.69758107921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0584520963
GSE13712_SHEARUp0.7082419630
GSE13712_STATICUp0.1349829765
GSE19018Down-0.0236206787
GSE19899_A1Down-0.0273698379
GSE19899_A2Up1.1319378197
PubMed_21979375_A1Up0.2221446602
PubMed_21979375_A2Up0.6953971581
GSE35957Up0.0897819928
GSE36640Down-0.0116241800
GSE54402Up0.3252579575
GSE9593Down-0.1666180019
GSE43922Up0.0876847893
GSE24585Down-0.1887988760
GSE37065Down-0.1013331390
GSE28863_A1Down-0.4470983629
GSE28863_A2Down-0.1978582847
GSE28863_A3Up0.3607721746
GSE28863_A4Up0.0391589607
GSE48662Down-0.0347602006

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL216543CHEMBL27838Q15078
CHEMBL440411CHEMBL27838Q15078
CHEMBL261425CHEMBL27838Q15078
CHEMBL411645CHEMBL27838Q15078
CHEMBL327004CHEMBL27836Q15078
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  • Drugs

Name

Drug

Accession number

Indirubin-3'-MonoximeDB02052 EXPT01949
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINEDB07364 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029817MicroarrayFunctional MTI (Weak)19088304
hsa-miR-196b-5pMIMAT0001080MIRT042678CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20181942Activation of CDK5 in neurons depends on its activators p35 and p39; however, little is known about how CDK5 is activated in non-neuronal senescent cells
20181942Here we report that p35 is required for the activation of CDK5 in the process of cellular senescence
20181942We demonstrate that: (i) p35 is expressed in osteosarcoma cells, (ii) p35 is required for CDK5 activation induced by pRB during senescence, (iii) p35 is required for the senescent morphological changes in which CDK5 is known to be involved as well as for expression of the senescence secretome, and (iv) p35 is up-regulated in senescing cells
20181942Taken together, these results suggest that p35 is at least one of the activators of CDK5 that is mobilized in the process of cellular senescence, which may provide insight into cancer cell proliferation and future cancer therapeutics
8557097The intracellular localization of p35 also differs markedly in young and aging animals
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