HCSGD entry for SGPL1

1. General information

Official gene symbolSGPL1
Entrez ID8879
Gene full namesphingosine-1-phosphate lyase 1
Other gene symbolsS1PL SPL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001553LuteinizationIEAbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006672Ceramide metabolic processIDAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008117Sphinganine-1-phosphate aldolase activityIDA NASmolecular_function
GO:0008209Androgen metabolic processIEAbiological_process
GO:0008210Estrogen metabolic processIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010761Fibroblast migrationIEAbiological_process
GO:0016831Carboxy-lyase activityIEAmolecular_function
GO:0019752Carboxylic acid metabolic processIEAbiological_process
GO:0030097HemopoiesisIEAbiological_process
GO:0030148Sphingolipid biosynthetic processTASbiological_process
GO:0030149Sphingolipid catabolic processNASbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0030176Integral component of endoplasmic reticulum membraneNAScellular_component
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayIEAbiological_process
GO:0048705Skeletal system morphogenesisIEAbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0097194Execution phase of apoptosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19719361350.33913786710.85908363671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4593506107
GSE13712_SHEARUp0.6378509421
GSE13712_STATICUp0.4958417446
GSE19018Down-0.2045877761
GSE19899_A1Up0.1272325093
GSE19899_A2Up0.3542382495
PubMed_21979375_A1Up0.4578211828
PubMed_21979375_A2Up0.7945089328
GSE35957Down-0.3867755636
GSE36640Down-0.2792230450
GSE54402Down-0.0766598610
GSE9593Up0.0171380988
GSE43922Up0.4493407106
GSE24585Down-0.0990301118
GSE37065Down-0.1945564429
GSE28863_A1Up0.0634918377
GSE28863_A2Down-0.3989956871
GSE28863_A3Down-0.2427508508
GSE28863_A4Up0.0207828801
GSE48662Up0.1332935039

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT002370Luciferase reporter assayFunctional MTI19635812
hsa-miR-155-5pMIMAT0000646MIRT020949ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT023023MicroarrayFunctional MTI (Weak)18668037
hsa-miR-7-5pMIMAT0000252MIRT025931MicroarrayFunctional MTI (Weak)19073608
hsa-miR-1226-3pMIMAT0005577MIRT036509CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b18056640
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.