HCSGD entry for RPS6KA4

1. General information

Official gene symbolRPS6KA4
Entrez ID8986
Gene full nameribosomal protein S6 kinase, 90kDa, polypeptide 4
Other gene symbolsMSK2 RSK-B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001818Negative regulation of cytokine productionTASbiological_process
GO:0004674Protein serine/threonine kinase activityIDA IEA IMPmolecular_function
GO:0004711Ribosomal protein S6 kinase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0016572Histone phosphorylationTASbiological_process
GO:0032793Positive regulation of CREB transcription factor activityTASbiological_process
GO:0033129Positive regulation of histone phosphorylationIMPbiological_process
GO:0035066Positive regulation of histone acetylationIMPbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0043987Histone H3-S10 phosphorylationIMPbiological_process
GO:0043988Histone H3-S28 phosphorylationIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0048273Mitogen-activated protein kinase p38 bindingIGImolecular_function
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0070498Interleukin-1-mediated signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95049072600.14050412220.99999024730.7210983048

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1975450771
GSE13712_SHEARUp0.1042708681
GSE13712_STATICDown-0.0420707536
GSE19018Down-0.1696703308
GSE19899_A1Down-0.2274044900
GSE19899_A2Down-0.1860500076
PubMed_21979375_A1Down-0.2430531647
PubMed_21979375_A2Up0.1259959525
GSE35957Up0.2106813433
GSE36640Down-0.0622529751
GSE54402Up0.0491919916
GSE9593Up0.1212800850
GSE43922Up0.0136875829
GSE24585Down-0.2834978549
GSE37065Down-0.1943168391
GSE28863_A1Down-0.2432042308
GSE28863_A2Down-0.1160931236
GSE28863_A3Down-0.0612734001
GSE28863_A4Up0.0251990921
GSE48662Down-0.3222021855

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Riboflavin MonophosphateDB03247 EXPT01458

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022283MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.