HCSGD entry for DUOXA1
1. General information
| Official gene symbol | DUOXA1 |
|---|---|
| Entrez ID | 90527 |
| Gene full name | dual oxidase maturation factor 1 |
| Other gene symbols | NIP NUMBIP mol |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0045666 | Positive regulation of neuron differentiation | IEA | biological_process |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4254056153 | 0.9391762927 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0031656284 |
| GSE13712_SHEAR | Down | -0.0408024250 |
| GSE13712_STATIC | Up | 0.0571361804 |
| GSE19018 | Up | 0.2328866575 |
| GSE19899_A1 | Up | 0.0791532954 |
| GSE19899_A2 | Up | 0.1073871498 |
| PubMed_21979375_A1 | Up | 0.1395795012 |
| PubMed_21979375_A2 | Down | -0.0333629798 |
| GSE35957 | Up | 0.1764814642 |
| GSE36640 | Up | 0.0368787721 |
| GSE54402 | Down | -0.0642251156 |
| GSE9593 | Up | 0.0782575965 |
| GSE43922 | Up | 0.1357925691 |
| GSE24585 | Down | -0.0299384867 |
| GSE37065 | Down | -0.0088213860 |
| GSE28863_A1 | Down | -0.0589074210 |
| GSE28863_A2 | Down | -0.0743255540 |
| GSE28863_A3 | Up | 0.3366863907 |
| GSE28863_A4 | Up | 0.0940043994 |
| GSE48662 | Up | 0.0883947824 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017747 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26880268 | Mol Cancer Ther; 15(5); 1074-81 |
| 26461417 | We have studied proteasome function in replicative senescence and cell survival (Mol Aspects Med 35, 1-71, 2014) |
| 25286678 | 33 mol/L H2O2 at 0 h, 1 h, 2 h were detected by comet electrophoresis and Western blot |
| 24191234 | Cellular senescence was induced using a stress-induced premature senescence protocol consisting of three successive once-daily exposure of cells to 1x10(-8) mol/L angiotensin II and was dependent upon the type-1 angiotensin II receptor |
| 22855034 | VSMCs obtained from the young rats were served as the young control group; VSMCs obtained from the old rats were treated with no drug (the old group), with low dose extracts (20 mg/L, the EXT low-concentration group) and high dose extracts (40 mg/L, the EXT high concentration group), and with Probucal (10(-6) mol/L, the Probucal group) as a positive control |
| 21468560 | The cells were synchronized and divided into a normal control group, an AngII group (AngII, 10(-)(6) mol/l) and an AngII + losartan group (losartan, 10(-)(5) mol/l), and were then cultured for 72 h |
| 18441278 | Cell Mol |
| 18031568 | Treatment of cultured neonatal rat cardiomyocytes with a low concentration of doxorubicin (DOX) (10(-7) mol L(-1)) did not induce apoptosis but did induce oxidative stress, which was confirmed by 2',7'-dichlorofluorescin diacetate staining |
| 16306232 | Down-regulation of the candidate neuron-specific genes for N-methyl-D-aspartate (NMDA) receptor subunits (NMDAzeta1 and -epsilon2) and neurofilament light peptide (NF-L) were found to be characteristic of the aging process as reported in vivo (Brain Res 907:71-83, 2001; Brain Res Mol Brain Res 99:40-45, 2002) |
| 12877804 | RESULTS: Both 25 micro mol/L and 50 micro mol/L concentrations of LY294002 could cause a significant decrease in cells entering into S phase, and this cell cycle of G(1) phase arrest was dose-dependent |
| 12180124 | Chemiluminescence of isolated non-parenchymal rat liver cells was measured after phagocytosis of opsonized zymosan or phorbolymristate acetate (PMA) stimulation, in the presence and absence of large unilamellar vesicles (LUVs) containing 25 mol% phosphatidylserine (PS) or 50 mol% cardiolipin (CL) and complementary molar ratio of phosphatidylcholine (PC) |
| 7541795 | 18 nM (mol PS liposomes/l), but not phosphatidylcholine, phosphatidylethanolamine, or sphingomyelin liposomes |
| 2779555 | Ozer, Mol |
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