HCSGD entry for ACVR1B

1. General information

Official gene symbolACVR1B
Entrez ID91
Gene full nameactivin A receptor, type IB
Other gene symbolsACTRIB ACVRLK4 ALK4 SKR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIDAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001942Hair follicle developmentIEAbiological_process
GO:0004674Protein serine/threonine kinase activityEXP IDAmolecular_function
GO:0004675Transmembrane receptor protein serine/threonine kinase activityNASmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007178Transmembrane receptor protein serine/threonine kinase signaling pathwayTASbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016361Activin receptor activity, type IIDA TASmolecular_function
GO:0017002Activin-activated receptor activityIDAmolecular_function
GO:0018107Peptidyl-threonine phosphorylationIDA IEAbiological_process
GO:0019838Growth factor bindingIPImolecular_function
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0031625Ubiquitin protein ligase bindingNASmolecular_function
GO:0032924Activin receptor signaling pathwayIDA IEA IMPbiological_process
GO:0032927Positive regulation of activin receptor signaling pathwayIDAbiological_process
GO:0034711Inhibin bindingIPImolecular_function
GO:0038092Nodal signaling pathwayIGIbiological_process
GO:0045648Positive regulation of erythrocyte differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046332SMAD bindingIDA IEAmolecular_function
GO:0046545Development of primary female sexual characteristicsIEAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048185Activin bindingIDA IEAmolecular_function
GO:0097191Extrinsic apoptotic signaling pathwayIMPbiological_process
GO:1901165Positive regulation of trophoblast cell migrationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09496073860.93952536000.64518884871.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1295165507
GSE13712_SHEARUp0.0116975061
GSE13712_STATICUp0.0162296037
GSE19018Down-0.0604485467
GSE19899_A1Up0.2274357010
GSE19899_A2Up0.2493999482
PubMed_21979375_A1Up0.7189281703
PubMed_21979375_A2Up0.2164555276
GSE35957Up0.1455263173
GSE36640Up0.2318232158
GSE54402Up0.0314997898
GSE9593Up0.1803510170
GSE43922Up0.4942086430
GSE24585Up0.2380391691
GSE37065Up0.0346041714
GSE28863_A1Up0.4929659184
GSE28863_A2Down-0.5020741350
GSE28863_A3Down-0.0971823789
GSE28863_A4Down-0.0421924154
GSE48662Up0.0368977478

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-210-3pMIMAT0000267MIRT003185immunoprecipitaion//qRT-PCRFunctional MTI (Weak)19826008
hsa-miR-24-3pMIMAT0000080MIRT003830Western blot//Luciferase reporter assay//Reporter assay;OtherFunctional MTI17906079
hsa-miR-7-5pMIMAT0000252MIRT025920MicroarrayFunctional MTI (Weak)17612493
hsa-miR-182-5pMIMAT0000259MIRT047200CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048108CLASHFunctional MTI (Weak)23622248
hsa-miR-26b-5pMIMAT0000083MIRT050048CLASHFunctional MTI (Weak)23622248
hsa-miR-15a-5pMIMAT0000068MIRT051312CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051801CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052392CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-24-3pMIMAT00000802hsa-miR-24{Western blot}{overexpression by miRNA precursor transfection}17906079
hsa-miR-24-3pMIMAT00000801hsa-miR-24{Western blot}{overexpression by miRNA precursor transfection}17906079
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.