HCSGD entry for DGKI
1. General information
| Official gene symbol | DGKI |
|---|---|
| Entrez ID | 9162 |
| Gene full name | diacylglycerol kinase, iota |
| Other gene symbols | DGK-IOTA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003951 | NAD+ kinase activity | IEA | molecular_function |
| GO:0004143 | Diacylglycerol kinase activity | IEA | molecular_function |
| GO:0005095 | GTPase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0017016 | Ras GTPase binding | IEA | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0032045 | Guanyl-nucleotide exchange factor complex | IEA | cellular_component |
| GO:0032317 | Regulation of Rap GTPase activity | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0046579 | Positive regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1072056381 | 0.2837142510 | 0.6801059532 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2840617433 |
| GSE13712_SHEAR | Down | -0.0782052597 |
| GSE13712_STATIC | Up | 0.0325744284 |
| GSE19018 | Down | -2.5094941628 |
| GSE19899_A1 | Up | 0.0082914413 |
| GSE19899_A2 | Down | -0.8427158247 |
| PubMed_21979375_A1 | Down | -0.1888677626 |
| PubMed_21979375_A2 | Up | 0.1396266694 |
| GSE35957 | Up | 0.8462226380 |
| GSE36640 | Down | -0.2718946444 |
| GSE54402 | Up | 0.0818666382 |
| GSE9593 | Up | 0.3494204835 |
| GSE43922 | Up | 0.2579102862 |
| GSE24585 | Up | 0.0781727281 |
| GSE37065 | Up | 0.4562721488 |
| GSE28863_A1 | Up | 0.1277880749 |
| GSE28863_A2 | Up | 0.0985824563 |
| GSE28863_A3 | Up | 0.0761960800 |
| GSE28863_A4 | Up | 0.2399057176 |
| GSE48662 | Up | 0.2057992120 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028926 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
