HCSGD entry for CD34

1. General information

Official gene symbolCD34
Entrez ID947
Gene full nameCD34 molecule
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001894Tissue homeostasisIDAbiological_process
GO:0001935Endothelial cell proliferationIDAbiological_process
GO:0003094Glomerular filtrationIEPbiological_process
GO:0003158Endothelium developmentIEPbiological_process
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeISScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006536Glutamate metabolic processIDAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionIEPbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008217Regulation of blood pressureIDAbiological_process
GO:0008283Cell proliferationISSbiological_process
GO:0009897External side of plasma membraneIC IDAcellular_component
GO:0009925Basal plasma membraneISScellular_component
GO:0010628Positive regulation of gene expressionIEPbiological_process
GO:0010629Negative regulation of gene expressionIMPbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016324Apical plasma membraneISScellular_component
GO:0016337Cell-cell adhesionIDAbiological_process
GO:0030097HemopoiesisIMPbiological_process
GO:0030195Negative regulation of blood coagulationIDAbiological_process
GO:0030246Carbohydrate bindingIDAmolecular_function
GO:0032720Negative regulation of tumor necrosis factor productionIDAbiological_process
GO:0032733Positive regulation of interleukin-10 productionIDAbiological_process
GO:0035759Mesangial cell-matrix adhesionISSbiological_process
GO:0036053Glomerular endothelium fenestraISScellular_component
GO:0038001Paracrine signalingIDAbiological_process
GO:0042482Positive regulation of odontogenesisIDAbiological_process
GO:0043199Sulfate bindingIEAmolecular_function
GO:0045019Negative regulation of nitric oxide biosynthetic processIDAbiological_process
GO:0045171Intercellular bridgeIDAcellular_component
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048870Cell motilityIEPbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0050900Leukocyte migrationISSbiological_process
GO:0060290TransdifferentiationIEPbiological_process
GO:0060547Negative regulation of necrotic cell deathIDAbiological_process
GO:0061042Vascular wound healingIEPbiological_process
GO:0071425Hematopoietic stem cell proliferationIMPbiological_process
GO:0071636Positive regulation of transforming growth factor beta productionIDAbiological_process
GO:0071657Positive regulation of granulocyte colony-stimulating factor productionIDA IEPbiological_process
GO:0071971Extracellular vesicular exosome assemblyIDAbiological_process
GO:0072011Glomerular endothelium developmentIEPbiological_process
GO:0072089Stem cell proliferationIEPbiological_process
GO:0072254Metanephric glomerular mesangial cell differentiationIEPbiological_process
GO:1900035Negative regulation of cellular response to heatIDAbiological_process
GO:1900038Negative regulation of cellular response to hypoxiaIDAbiological_process
GO:1900041Negative regulation of interleukin-2 secretionIMPbiological_process
GO:1900168Positive regulation of glial cell line-derived neurotrophic factor secretionIDAbiological_process
GO:2001214Positive regulation of vasculogenesisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06420161090.60339392880.54628791211.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0386761104
GSE13712_SHEARDown-1.8003074979
GSE13712_STATICDown-0.9909445313
GSE19018Down-0.0039497384
GSE19899_A1Up0.0385202155
GSE19899_A2Up0.2176056574
PubMed_21979375_A1Down-0.0804148030
PubMed_21979375_A2Down-0.0076558700
GSE35957Down-0.0023951387
GSE36640Up0.0397736082
GSE54402Up0.0630667828
GSE9593Up0.1933427297
GSE43922Up0.0386523276
GSE24585Up0.1228663639
GSE37065Up0.4312073964
GSE28863_A1Up1.8755741284
GSE28863_A2Up1.0012636347
GSE28863_A3Up0.1165360246
GSE28863_A4Up0.0995351573
GSE48662Down-0.0134981747

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT004052Luciferase reporter assay//Microarray//Western blot//Reporter assay;Western blotFunctional MTI18308931
hsa-miR-106b-5pMIMAT0000680MIRT020428MicroarrayFunctional MTI (Weak)17242205
hsa-miR-9-5pMIMAT0000441MIRT021486Western blotFunctional MTI18308931
hsa-miR-24-3pMIMAT0000080MIRT030549qRT-PCRFunctional MTI (Weak)19748357
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 25 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26546739A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition
26196672All cells were negative for leukocyte markers (CD19, CD34, CD45) and CD73 positive
26168818Immunohistochemical evaluation using CD34 antibody confirmed the reduced vessel density in NAX014 group
25993799RESULT: The purity of the CD34 + CD38 - cells is (91
25879198Human DPSCs, formerly immune-selected for STRO-1 and c-Kit, were separated for negativity and positivity to CD34 expression respectively, and evaluated for cell proliferation, stemness maintenance, cell senescence and multipotency
25874702At day-2 and day-7 after AMI onset, circulating-EPCs (CD34+ Flk1+) were quantified by flow cytometry
25693733Fucoidan-preconditioning of senescent ECFCs was shown by flow cytometry to restore the expression of functional ECFC surface markers (CD34, c-Kit, VEGFR2, and CXCR4) and stimulate the in vitro tube formation capacity of ECFCs
25407160In this study, tauroursodeoxycholic acid (TUDCA) induced dissociation of CD34(+) hematopoietic stem cells (HSCs) from stromal cells by reducing adhesion molecule expression
25407160In addition, TUDCA increased differentiation of CD34(+) HSCs into EPC lineage cells via Akt activation
25407160In the mouse hind limb ischemia model, TUDCA promoted blood perfusion by enhancing angiogenesis through recruitment of Flk-1(+) /CD34(+) and Sca-1(+) /c-kit(+) progenitors into damaged tissue
25300954We tested whether heritable epigenetic processes in long-lived CD34(+) haematopoietic stem/progenitor cells showed evidence for re-programming associated with the extremes of fetal growth
25059386Therefore, the present study aims to reinforce this idea by comparing lung TCs with endothelial cells (ECs), since TCs and ECs share immunopositivity for CD34
24804814Cell senescence and microvessel density were evaluated by SA-beta-gal staining and CD34 staining, respectively
23106472The cells harvested by both methods gave positive results for CD44 and CD90 and negative results for CD34 and CD45
22721583Both PB-MSCs and BM-MSCs were positive for CD44 and CD90, and negative for CD34 and CD45
21427290Using purified CD34(+) hematopoietic progenitor cells and differentiated myeloid cell populations from the same human samples, we obtained detailed methylation profiles at distinct stages of hematopoiesis
21427290We identified a defined set of differentiation-related genes that are methylated in CD34(+) hematopoietic progenitor cells but show pronounced DNA hypomethylation in monocytes and in granulocytes
21408175Analyzing CD34+ and CD34- stem/progenitor cells we observed an increase of endogenous gammaH2AX-foci levels with advancing donor age, associated with an age-related decline in telomere length
21176525RESULTS: Flow cytometry results showed the detection rates for CD29, CD34 and CD45 were 97
20852063Efficient nonadhesive ex vivo expansion of early endothelial progenitor cells derived from CD34+ human cord blood fraction for effective therapeutic vascularization
20852063Compared to mononuclear cells, the CD34(+) fraction was superior in its expansion of functional EPCs that could differentiate into acLDL/UEA-1(+) cells without significant cellular senescence, whereas the CD34(-) fraction showed no EPC expansion
20852063Among the cytokine combinations tested for the CD34(+) fraction, a combination (SFIb) consisting of stem cell factor (SCF), FMS-like tyrosine kinase 3 ligand, interleukin-3, and basic fibroblast growth factor resulted in a reproducible 64- to 1468-fold EPC expansion from various cord blood origins
20852063Taken together, these results suggest that the nonadhesive serum-free culture conditions of the CD34(+) fraction provide an effective EPC expansion method for cell therapy, and an expansion condition leading to high percentages of CD34(+) cells and blasts is likely important in EPC expansion
20424141Results of flow cytometry showed that EPCs after 7 days of culture expressed both stem cell markers CD34 and CD133 and endothelial cell markers VEGFR-2 (flk-1) and VE-cadherin
20132052FACS analysis confirmed expression of the stem cell markers CD44, CD90, CD105, and CD166, but negative expression of CD34 and CD45 ruling out a hematopoietic or fibrocyte origin for these progenitors
19723023Vascular reactive hyperaemic FBF response, resting CD34+ and CD34+/VEGFR2+ (vascular endothelial growth factor receptor 2+] cell number, CFU-EC (colony forming unit-endothelial cell) count and CFU-EC senescence were evaluated
18206730Here, we describe in vitro and in vivo validation of the phase I/II protocol for CD34+ expansion of thawed CB units according to the current Cell Therapy Products (CTPs) Guidelines
18206730MATERIALS AND METHODS: CB units were thawed and 25% of the total volume was processed for CD34+ selection by CliniMACS
17545049The expressions of CD29, CD44, and CD34 were observed in ASCs by flow cytometry while HLA-DR or CD133 expression was not detected
16946301We transduced healthy human CD34(+) peripheral blood-mobilized stem cells (PBSCs) with retrovirus vector encoding wild-type (wt) CXCR4 or WHIM-type mutated CXCR4 and studied these cells ex vivo in culture and after engraftment in a nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse xenograft model
14656709The implantation of expanded CD34(+) endothelial progenitor cells has the capacity to induce angiogenesis
14656709After 2 wk of culture with the addition of several growth factors, the CD117(+) stem cells expanded approximately 20-fold and had an endothelial phenotype with high expression of CD34 and vascular endothelial-cadherin
12852251Human CD34+ hematopoietic stem and progenitor cells are capable of maintaining a life-long supply of the entire spectrum of blood cells dependent on systemic needs
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