HCSGD entry for BAG3

1. General information

Official gene symbolBAG3
Entrez ID9531
Gene full nameBCL2-associated athanogene 3
Other gene symbolsBAG-3 BIS CAIR-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006457Protein foldingNASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIDAbiological_process
GO:0010664Negative regulation of striated muscle cell apoptotic processIEAbiological_process
GO:0021510Spinal cord developmentIEAbiological_process
GO:0030018Z discIEAcellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0043005Neuron projectionIEAcellular_component
GO:0043066Negative regulation of apoptotic processNASbiological_process
GO:0050821Protein stabilizationIEAbiological_process
GO:0051087Chaperone bindingIEAmolecular_function
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05936158580.97815383530.52767858831.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1340227523
GSE13712_SHEARUp0.3849875494
GSE13712_STATICUp0.2319088677
GSE19018Up0.6190177797
GSE19899_A1Down-0.0019767678
GSE19899_A2Up0.4487441551
PubMed_21979375_A1Up0.0503953409
PubMed_21979375_A2Up0.2481588349
GSE35957Up0.1344252717
GSE36640Up0.7836237621
GSE54402Up0.1571483594
GSE9593Up0.2737206192
GSE43922Down-0.0687268616
GSE24585Up0.0218814838
GSE37065Down-0.1157515160
GSE28863_A1Up0.0821953020
GSE28863_A2Up0.1512646198
GSE28863_A3Up0.4045677066
GSE28863_A4Up0.0103240657
GSE48662Down-0.2536360775

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029481MicroarrayFunctional MTI (Weak)19088304
hsa-miR-221-3pMIMAT0000278MIRT046955CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24997994We applied a quantitative proteomics screen to identify signals that lead to therapy-induced senescence and discovered that Bcl2-associated athanogene 3 (Bag3) is up-regulated after adriamycin treatment in MCF7 cells
24997994Bag3 is a member of the BAG family of co-chaperones that interacts with Hsp70
24997994Bag3 also regulates major cell-signaling pathways
24997994Mass spectrometry analysis of the Bag3 Complex revealed a novel interaction between Bag3 and Major Vault Protein (MVP)
24997994Silencing of Bag3 or MVP shifts the cellular response to adriamycin to favor apoptosis
24997994We demonstrate that Bag3 and MVP contribute to apoptosis resistance in therapy-induced senescence by increasing the level of activation of extracellular signal-regulated kinase1/2 (ERK1/2)
24997994Silencing of either Bag3 or MVP decreased ERK1/2 activation and promoted apoptosis in adriamycin-treated cells
24997994We propose a model in which Bag3 binds to MVP and facilitates MVP accumulation in the nucleus, which sustains ERK1/2 activation
24997994We confirmed that silencing of Bag3 or MVP shifts the response toward apoptosis and regulates ERK1/2 activation in a panel of diverse breast cancer cell lines
21681022BAG3 and friends: co-chaperones in selective autophagy during aging and disease
21681022There is a reciprocal change in the expression of two members of the BAG (Bcl-2-associated athanogen) family, BAG1 and BAG3, during cellular aging and under acute stress ("BAG1-BAG3-switch")
21681022BAG3 was recently described as a mediator of a novel macroautophagy pathway that uses the specificity of heat shock protein 70 (HSP70) to misfolded proteins and also involves other protein partners, such as HSPB8
21681022Interestingly, aggresome-targeting by BAG3 does not depend on substrate ubiquitination and is, therefore, involved in the clearance of misfolded proteins that are not ubiquitinated
19229298Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
19229298We examined the specific roles of BAG1 and BAG3 in protein degradation during the aging process
19229298We show that BAG1 and BAG3 regulate proteasomal and macroautophagic pathways, respectively, for the degradation of polyubiquitinated proteins
19229298Moreover, using models of cellular aging, we find that a switch from BAG1 to BAG3 determines that aged cells use more intensively the macroautophagic system for turnover of polyubiquitinated proteins
19229298The BAG3/BAG1 ratio is also elevated in neurons during aging of the rodent brain, where, consistent with a higher macroautophagy activity, we find increased levels of the autophagosomal marker LC3-II as well as a higher cathepsin activity
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