HCSGD entry for CD59
1. General information
| Official gene symbol | CD59 |
|---|---|
| Entrez ID | 966 |
| Gene full name | CD59 molecule, complement regulatory protein |
| Other gene symbols | 16.3A5 1F5 EJ16 EJ30 EL32 G344 HRF-20 HRF20 MAC-IP MACIF MEM43 MIC11 MIN1 MIN2 MIN3 MIRL MSK21 p18-20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001775 | Cell activation | IBA | biological_process |
| GO:0001848 | Complement binding | IBA | molecular_function |
| GO:0001971 | Negative regulation of activation of membrane attack complex | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IBA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0031362 | Anchored component of external side of plasma membrane | IDA | cellular_component |
| GO:0042102 | Positive regulation of T cell proliferation | IEA | biological_process |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0043218 | Compact myelin | IEA | cellular_component |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0189338399 | 0.9755382812 | 0.3364343455 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3298754154 |
| GSE13712_SHEAR | Up | 0.1066098596 |
| GSE13712_STATIC | Up | 0.1755693326 |
| GSE19018 | Up | 0.7378642401 |
| GSE19899_A1 | Up | 0.1608809663 |
| GSE19899_A2 | Down | -0.0241839144 |
| PubMed_21979375_A1 | Down | -0.4215018495 |
| PubMed_21979375_A2 | Up | 0.1232087062 |
| GSE35957 | Up | 0.9232047396 |
| GSE36640 | Up | 0.4863995208 |
| GSE54402 | Up | 0.1719633686 |
| GSE9593 | Up | 0.7943899852 |
| GSE43922 | Down | -0.0201536371 |
| GSE24585 | Up | 0.4604203205 |
| GSE37065 | Up | 0.2297065205 |
| GSE28863_A1 | Down | -0.2557223448 |
| GSE28863_A2 | Up | 0.3094133183 |
| GSE28863_A3 | Down | -0.0339589571 |
| GSE28863_A4 | Up | 0.2215648853 |
| GSE48662 | Down | -0.2648585957 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002624 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002624 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047711 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049073 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22206234 | METHODS: A cross sectional study was conducted in the north-east coast of Tanzania to investigate whether the changes in glycosylphosphatidylinositol (GPI)-anchored complement regulatory proteins (CD55 and CD59) contributes to malaria anaemia |
| 22206234 | Levels of CD55 and CD59 were measured by flow cytometer and compared between anaemic (8 |
| 22206234 | RESULTS: Levels of CD55 and CD59 decreased with increased RBC age |
| 22206234 | Levels of CD59 were lower in anaemic children, but these differences were not significant |
| 22206234 | CD55, but not CD59, levels correlated positively with the level of haemoglobin in anaemic children |
| 22016805 | A range of typical vesicular components, also involved in RBCs senescence, like Band 3, CD59, hemoglobin and carbonylated membrane proteins were found to physically interact with sCLU |
| 17188915 | RBC membrane molecules CD55 and CD59 along with phosphatydylserine and CD47 were measured |
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