HCSGD entry for TTI1
1. General information
| Official gene symbol | TTI1 |
|---|---|
| Entrez ID | 9675 |
| Gene full name | TELO2 interacting protein 1 |
| Other gene symbols | KIAA0406 smg-10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0031931 | TORC1 complex | IDA | cellular_component |
| GO:0031932 | TORC2 complex | IDA | cellular_component |
| GO:0032006 | Regulation of TOR signaling | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7205656320 | 0.1929590213 | 0.9999902473 | 0.8517314104 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3344737504 |
| GSE13712_SHEAR | Down | -0.0121917006 |
| GSE13712_STATIC | Up | 0.1707157685 |
| GSE19018 | Down | -0.1735434672 |
| GSE19899_A1 | Down | -0.2314923798 |
| GSE19899_A2 | Down | -0.6707242565 |
| PubMed_21979375_A1 | Down | -0.2470389331 |
| PubMed_21979375_A2 | Up | 0.0115212042 |
| GSE35957 | Down | -0.2705507397 |
| GSE36640 | Down | -1.3948287116 |
| GSE54402 | Up | 0.0498453323 |
| GSE9593 | Down | -0.5094569473 |
| GSE43922 | Down | -0.1373139679 |
| GSE24585 | Up | 0.1541115575 |
| GSE37065 | Up | 0.1090157973 |
| GSE28863_A1 | Up | 0.3990626150 |
| GSE28863_A2 | Up | 0.2264424594 |
| GSE28863_A3 | Down | -0.1099347548 |
| GSE28863_A4 | Up | 0.0891669973 |
| GSE48662 | Up | 0.0736943684 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027488 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26833729 | Our data suggest that DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK (phosphatidylinositol 3-kinase-related kinase) family kinase, leading to reduced ATM-p53 signaling and senescence bypass |
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