HCSGD entry for CD79A
1. General information
| Official gene symbol | CD79A |
|---|---|
| Entrez ID | 973 |
| Gene full name | CD79a molecule, immunoglobulin-associated alpha |
| Other gene symbols | IGA MB-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004888 | Transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0005771 | Multivesicular body | ISS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0009897 | External side of plasma membrane | ISS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019815 | B cell receptor complex | ISS | cellular_component |
| GO:0030183 | B cell differentiation | ISS | biological_process |
| GO:0042100 | B cell proliferation | ISS | biological_process |
| GO:0042113 | B cell activation | ISS | biological_process |
| GO:0045121 | Membrane raft | ISS | cellular_component |
| GO:0050853 | B cell receptor signaling pathway | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4458816990 | 0.2918822841 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0088896290 |
| GSE13712_SHEAR | Up | 0.0325254890 |
| GSE13712_STATIC | Down | -0.1839783421 |
| GSE19018 | Up | 0.1399332644 |
| GSE19899_A1 | Down | -0.0355998595 |
| GSE19899_A2 | Up | 0.1215192767 |
| PubMed_21979375_A1 | Up | 0.1431094291 |
| PubMed_21979375_A2 | Down | -0.0161753864 |
| GSE35957 | Up | 0.2917764724 |
| GSE36640 | Up | 0.0121871423 |
| GSE54402 | Up | 0.1336934911 |
| GSE9593 | Up | 0.0215920132 |
| GSE43922 | Up | 0.0238246684 |
| GSE24585 | Up | 0.0261831759 |
| GSE37065 | Down | -0.1242633937 |
| GSE28863_A1 | Down | -0.8342856806 |
| GSE28863_A2 | Down | -0.9209543356 |
| GSE28863_A3 | Up | 0.4207947445 |
| GSE28863_A4 | Up | 0.0070437976 |
| GSE48662 | Up | 0.7974879792 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017240 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27127888 | Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity |
| 27127888 | IgA nephropathy(IgAN) is the most common primary glomerular disease in China |
| 27127888 | Only PLAU, JUN, and FOS were related to DNA damage, telomere dysfunction-induced aging markers, neutrophil function and IgA nephropathy |
| 27127888 | We conclude that DNA damage and telomere dysfunction could play important roles in IgA nephropathy |
| 27127888 | The networks of these markers showed the mechanism pathways that are involved in the duration of the occurrence and progression of IgA nephropathy and might be a new therapeutic opportunity for disease treatment |
| 22633096 | Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy |
| 16312260 | Chromosomal telomere shortening of kidney cells in IgA nephropathy by the measurement of DNA in urinary sediment |
| 16312260 | We investigated whether IgA nephropathy, a prototype chronic kidney disease, is associated with localized intrarenal cellular ageing |
| 7504839 | Anti-Gal is also present as IgA antibodies in body secretions such as saliva, milk and colostrum |
| 2108952 | There was a close correlation between the amounts of IgA and secretory component in the cells of Hassall's corpuscles and the thymus may have to be regarded as a part of the secretory-IgA system |
| 2108952 | The presence of albumin may represent a passive uptake of protein in senescent cells but a more active uptake of Igs, particularly IgG and IgA, could be postulated |
| 1059140 | RBC treated in the same way but incubated in IgM or Iga, Ig-depleter serum, or Medium 199 alone were not phagocytized |
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