HCSGD entry for PSMD6

1. General information

Official gene symbolPSMD6
Entrez ID9861
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 6
Other gene symbolsRpn7 S10 SGA-113M p42A p44S10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexIEA NAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006200ATP catabolic processNASbiological_process
GO:0006508ProteolysisNASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016887ATPase activityNASmolecular_function
GO:0022624Proteasome accessory complexISScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95622199760.04497037730.99999024730.3989434783

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2025364614
GSE13712_SHEARDown-0.1120196653
GSE13712_STATICUp0.0278095795
GSE19018Down-0.3307083037
GSE19899_A1Down-0.0697097510
GSE19899_A2Up0.0032717127
PubMed_21979375_A1Down-0.0069407956
PubMed_21979375_A2Up0.2187731439
GSE35957Up0.0859921234
GSE36640Down-0.0285476344
GSE54402Up0.2586373113
GSE9593Up0.0458871399
GSE43922Down-0.0237977514
GSE24585Down-0.1830921248
GSE37065Down-0.1701018107
GSE28863_A1Down-0.4296588372
GSE28863_A2Down-0.8148436247
GSE28863_A3Down-0.4990794398
GSE28863_A4Down-0.3623847115
GSE48662Down-0.4475938258

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024707MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026186MicroarrayFunctional MTI (Weak)19074876
hsa-miR-423-5pMIMAT0004748MIRT038175CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043296CLASHFunctional MTI (Weak)23622248
hsa-miR-219a-5pMIMAT0000276MIRT046979CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22473755The 19S proteasome subunit Rpn7 stabilizes DNA damage foci upon genotoxic insult
22473755Importantly, two 19S subunits, Rpn7 and Rpn11, colocalize with DNA damage foci over their whole lifespan
22473755Although silencing of Rpn11 does not affect foci stability and lifespan, silencing of Rpn7 promotes faster resolution of DNA damage foci following genotoxic insult
22473755For the first time, we provide evidence that Rpn7 silencing specifically decreases the frequencies of long-lived DNA damage foci without, however, affecting the repair rate of short-lived foci
22473755Therefore, we propose that interaction of Rpn7 with DDR foci in situ mediates the protection of DNA damage foci from premature resolution
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