HCSGD entry for TNFSF15
1. General information
| Official gene symbol | TNFSF15 |
|---|---|
| Entrez ID | 9966 |
| Gene full name | tumor necrosis factor (ligand) superfamily, member 15 |
| Other gene symbols | TL1 TL1A VEGI VEGI192A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | TAS | molecular_function |
| GO:0005123 | Death receptor binding | IEA | molecular_function |
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005164 | Tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007250 | Activation of NF-kappaB-inducing kinase activity | IDA | biological_process |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0042107 | Cytokine metabolic process | IDA | biological_process |
| GO:0050715 | Positive regulation of cytokine secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000068576 | 0.7621263896 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5056622829 |
| GSE13712_SHEAR | Up | 0.8596657441 |
| GSE13712_STATIC | Up | 1.4051765310 |
| GSE19018 | Down | -0.5944119553 |
| GSE19899_A1 | Up | 7.5998315391 |
| GSE19899_A2 | Up | 8.9136202416 |
| PubMed_21979375_A1 | Up | 9.2946409325 |
| PubMed_21979375_A2 | Up | 9.7325836560 |
| GSE35957 | Down | -1.3846646248 |
| GSE36640 | Up | 4.2746076893 |
| GSE54402 | Up | 5.7281324216 |
| GSE9593 | Down | -0.3778613610 |
| GSE43922 | Up | 5.9051924732 |
| GSE24585 | Down | -0.1314442767 |
| GSE37065 | Up | 0.1721510593 |
| GSE28863_A1 | Up | 0.1197675131 |
| GSE28863_A2 | Up | 0.3700727098 |
| GSE28863_A3 | Up | 0.0250248644 |
| GSE28863_A4 | Up | 0.2031096341 |
| GSE48662 | Up | 0.2562730057 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029860 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20675618 | Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding |
| 20675618 | Tumor necrosis factor-like cytokine 1A (TL1A) is expressed in endothelial cells and contributes to T-cell activation, via an extracellular fragment TL1A(L72-L251), generated by ectodomain shedding |
| 20675618 | Fragments of TL1A, referred to as vascular endothelial growth inhibitor, were found to induce growth arrest and apoptosis in endothelial cells; however, the underlying mechanisms remained obscure |
| 20675618 | Here, we show that full-length TL1A is the major detectable gene product in both human umbilical vein endothelial cells and circulating endothelial progenitor cells |
| 20675618 | TL1A expression was significantly enhanced in senescent circulating endothelial progenitor cells, and knockdown of TL1A partially reverted senescence |
| 20675618 | TL1A overexpression induced premature senescence in both circulating endothelial progenitor cells and human umbilical vein endothelial cells |
| 20675618 | We also identified a novel extracellular fragment of TL1A, TL1A(V84-L251), resulting from differential ectodomain shedding, which induced growth arrest and apoptosis in human umbilical vein endothelial cells |
| 20675618 | These findings suggest that TL1A is involved in the regulation of endothelial cell senescence, via a novel fragment produced by differential ectodomain shedding |
| 16626901 | In particular, a significant upregulation of interleukin-8, VEGI, and the IGF-binding proteins 3 and 5 was observed |
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