HCSGD entry for MED6
1. General information
| Official gene symbol | MED6 |
|---|---|
| Entrez ID | 10001 |
| Gene full name | mediator complex subunit 6 |
| Other gene symbols | NY-REN-28 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016592 | Mediator complex | IDA IEA IMP | cellular_component |
| GO:0019827 | Stem cell maintenance | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3080033319 | 0.3549149652 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2170272164 |
| GSE13712_SHEAR | Up | 0.3245687495 |
| GSE13712_STATIC | Up | 0.1967646582 |
| GSE19018 | Down | -0.4399124103 |
| GSE19899_A1 | Down | -0.0681942326 |
| GSE19899_A2 | Up | 0.1332643457 |
| PubMed_21979375_A1 | Up | 1.1508925232 |
| PubMed_21979375_A2 | Down | -0.4897982322 |
| GSE35957 | Down | -0.2602300946 |
| GSE36640 | Down | -0.7074359953 |
| GSE54402 | Up | 0.1586797644 |
| GSE9593 | Down | -0.1322666040 |
| GSE43922 | Up | 0.3013781134 |
| GSE24585 | Down | -0.0752358269 |
| GSE37065 | Up | 0.1562679545 |
| GSE28863_A1 | Up | 0.2640016433 |
| GSE28863_A2 | Up | 0.2211667746 |
| GSE28863_A3 | Down | -0.6128356248 |
| GSE28863_A4 | Up | 0.0566665823 |
| GSE48662 | Down | -0.2903181489 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-199a-3p | MIMAT0000232 | MIRT000781 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
| hsa-miR-199a-5p | MIMAT0000231 | MIRT004393 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027503 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
