HCSGD entry for HDAC6
1. General information
Official gene symbol | HDAC6 |
---|---|
Entrez ID | 10013 |
Gene full name | histone deacetylase 6 |
Other gene symbols | HD6 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000118 | Histone deacetylase complex | IDA | cellular_component |
GO:0000209 | Protein polyubiquitination | IEA | biological_process |
GO:0003779 | Actin binding | IEA | molecular_function |
GO:0004407 | Histone deacetylase activity | IDA IEA | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005634 | Nucleus | IDA ISS | cellular_component |
GO:0005730 | Nucleolus | IDA | cellular_component |
GO:0005737 | Cytoplasm | ISS | cellular_component |
GO:0005829 | Cytosol | IEA ISS | cellular_component |
GO:0005874 | Microtubule | IDA | cellular_component |
GO:0005875 | Microtubule associated complex | IDA | cellular_component |
GO:0005881 | Cytoplasmic microtubule | IEA | cellular_component |
GO:0005901 | Caveola | IDA | cellular_component |
GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
GO:0006476 | Protein deacetylation | IMP | biological_process |
GO:0006515 | Misfolded or incompletely synthesized protein catabolic process | IMP | biological_process |
GO:0006886 | Intracellular protein transport | IMP | biological_process |
GO:0007026 | Negative regulation of microtubule depolymerization | IEA | biological_process |
GO:0008013 | Beta-catenin binding | IPI | molecular_function |
GO:0008017 | Microtubule binding | IDA IEA ISS | molecular_function |
GO:0008270 | Zinc ion binding | IEA | molecular_function |
GO:0009636 | Response to toxic substance | IMP | biological_process |
GO:0009967 | Positive regulation of signal transduction | IMP | biological_process |
GO:0010033 | Response to organic substance | IMP | biological_process |
GO:0010469 | Regulation of receptor activity | IMP | biological_process |
GO:0010634 | Positive regulation of epithelial cell migration | IMP | biological_process |
GO:0010727 | Negative regulation of hydrogen peroxide metabolic process | IC | biological_process |
GO:0010870 | Positive regulation of receptor biosynthetic process | IMP | biological_process |
GO:0016234 | Inclusion body | IDA | cellular_component |
GO:0016235 | Aggresome | IDA | cellular_component |
GO:0016236 | Macroautophagy | IMP | biological_process |
GO:0016575 | Histone deacetylation | IDA ISS | biological_process |
GO:0016787 | Hydrolase activity | IEA | molecular_function |
GO:0019899 | Enzyme binding | ISS | molecular_function |
GO:0030286 | Dynein complex | IDA | cellular_component |
GO:0031252 | Cell leading edge | IDA | cellular_component |
GO:0031593 | Polyubiquitin binding | IDA | molecular_function |
GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | IEA | molecular_function |
GO:0032418 | Lysosome localization | IMP | biological_process |
GO:0034983 | Peptidyl-lysine deacetylation | IMP | biological_process |
GO:0035967 | Cellular response to topologically incorrect protein | IMP | biological_process |
GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
GO:0042903 | Tubulin deacetylase activity | IDA IEA ISS | molecular_function |
GO:0043014 | Alpha-tubulin binding | IDA | molecular_function |
GO:0043130 | Ubiquitin binding | IEA | molecular_function |
GO:0043162 | Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | IEA | biological_process |
GO:0043241 | Protein complex disassembly | IEA | biological_process |
GO:0043242 | Negative regulation of protein complex disassembly | IMP | biological_process |
GO:0045861 | Negative regulation of proteolysis | IMP | biological_process |
GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) | IEA | molecular_function |
GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific) | IEA | molecular_function |
GO:0048156 | Tau protein binding | IDA | molecular_function |
GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
GO:0048487 | Beta-tubulin binding | IEA | molecular_function |
GO:0051354 | Negative regulation of oxidoreductase activity | IC | biological_process |
GO:0051788 | Response to misfolded protein | IMP | biological_process |
GO:0051879 | Hsp90 protein binding | IDA | molecular_function |
GO:0060632 | Regulation of microtubule-based movement | IC | biological_process |
GO:0060765 | Regulation of androgen receptor signaling pathway | TAS | biological_process |
GO:0070201 | Regulation of establishment of protein localization | IEA | biological_process |
GO:0070301 | Cellular response to hydrogen peroxide | IMP | biological_process |
GO:0070840 | Dynein complex binding | IDA | molecular_function |
GO:0070842 | Aggresome assembly | IEA IMP | biological_process |
GO:0070845 | Polyubiquitinated misfolded protein transport | IMP | biological_process |
GO:0070846 | Hsp90 deacetylation | IEA IMP | biological_process |
GO:0070848 | Response to growth factor | IMP | biological_process |
GO:0071218 | Cellular response to misfolded protein | IEA | biological_process |
GO:0090035 | Positive regulation of chaperone-mediated protein complex assembly | IMP | biological_process |
GO:0090042 | Tubulin deacetylation | IDA ISS | biological_process |
GO:0097372 | NAD-dependent histone deacetylase activity (H3-K18 specific) | IEA | molecular_function |
GO:1901300 | Positive regulation of hydrogen peroxide-mediated programmed cell death | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.9331926257 | 0.1469632233 | 0.9999902473 | 0.7409586095 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.1236904405 |
GSE13712_SHEAR | Down | -0.3663003440 |
GSE13712_STATIC | Down | -0.4447799919 |
GSE19018 | Up | 0.2383197387 |
GSE19899_A1 | Down | -0.0048623084 |
GSE19899_A2 | Down | -0.2087722473 |
PubMed_21979375_A1 | Down | -0.2367222837 |
PubMed_21979375_A2 | Down | -0.1309570687 |
GSE35957 | Down | -0.3368465955 |
GSE36640 | Down | -0.3097840526 |
GSE54402 | Down | -0.1253225297 |
GSE9593 | Down | -0.1530842184 |
GSE43922 | Down | -0.2496157764 |
GSE24585 | Up | 0.3290292208 |
GSE37065 | Up | 0.1465763609 |
GSE28863_A1 | Up | 0.1282413648 |
GSE28863_A2 | Up | 0.2972692548 |
GSE28863_A3 | Down | -0.1693604627 |
GSE28863_A4 | Down | -0.1063848693 |
GSE48662 | Down | -0.0519200852 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
---|---|---|
Vorinostat | DB02546 | EXPT02902 |
SB939 | DB05223 | - |
Romidepsin | DB06176 | - |
Panobinostat | DB06603 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-335-5p | MIMAT0000765 | MIRT017204 | Microarray | Functional MTI (Weak) | 18185580 |
hsa-miR-181a-5p | MIMAT0000256 | MIRT047316 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
24156782 | In the functional study, AT13387 inhibited cell migration with downregulation of a cell migration regulator, HDAC6, and increased the acetylation and stabilization of alpha-tubulin |
21555914 | We recently identified a signaling network involving the acetyltransferase TIP60, the deacetylase HDAC6 and the SRPK kinases that regulates SRSF2 protein turnover through phosphorylation/acetylation modifications in response to cisplatin |
11257101 | This inappropriate deacetylation by HDAC4, HDAC5 and HDAC6 follows their relocalization from the cytoplasm to the nucleus |
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