HCSGD entry for HDAC5

1. General information

Official gene symbolHDAC5
Entrez ID10014
Gene full namehistone deacetylase 5
Other gene symbolsHD5 NY-CO-9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000118Histone deacetylase complexTAScellular_component
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEA IMPbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0003714Transcription corepressor activityIEAmolecular_function
GO:0004407Histone deacetylase activityIDAmolecular_function
GO:0005080Protein kinase C bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006325Chromatin organizationTASbiological_process
GO:0006338Chromatin remodelingTASbiological_process
GO:0006342Chromatin silencingTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010830Regulation of myotube differentiationISSbiological_process
GO:0010832Negative regulation of myotube differentiationIMPbiological_process
GO:0016568Chromatin modificationTASbiological_process
GO:0016575Histone deacetylationIDAbiological_process
GO:0016604Nuclear bodyIEAcellular_component
GO:0030183B cell differentiationTASbiological_process
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)IEAmolecular_function
GO:0032869Cellular response to insulin stimulusNASbiological_process
GO:0033555Multicellular organismal response to stressIEAbiological_process
GO:0042113B cell activationTASbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043393Regulation of protein bindingIMPbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)IEAmolecular_function
GO:0046970NAD-dependent histone deacetylase activity (H4-K16 specific)IEAmolecular_function
GO:0048742Regulation of skeletal muscle fiber developmentIEAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0070491Repressing transcription factor bindingIPImolecular_function
GO:0090051Negative regulation of cell migration involved in sprouting angiogenesisIMPbiological_process
GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific)IEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93207645230.01378830210.99999024730.2313217336

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2855734706
GSE13712_SHEARDown-0.6337212393
GSE13712_STATICDown-0.7548902229
GSE19018Up0.1202442295
GSE19899_A1Down-0.5236399417
GSE19899_A2Down-0.8263422153
PubMed_21979375_A1Down-1.3178637368
PubMed_21979375_A2Down-0.5827781936
GSE35957Up0.5465042853
GSE36640Down-0.1491003811
GSE54402Down-0.0168093437
GSE9593Up0.0460747508
GSE43922Down-0.7874517580
GSE24585Up0.3986826221
GSE37065Down-0.2085247573
GSE28863_A1Up0.1036734568
GSE28863_A2Down-0.2156474564
GSE28863_A3Down-0.3693029573
GSE28863_A4Down-0.1793917802
GSE48662Up0.5813447230

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PanobinostatDB06603 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029704MicroarrayFunctional MTI (Weak)19088304
hsa-let-7a-5pMIMAT0000062MIRT052514CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26443543Similarly, two stilbenes also stimulated LKB1, AMPKalpha, extracellular-signal related kinase 5 (ERK5) phosphorylation, and histone acetylase 5 (HDAC5) and Kruppel-like factor 2 (KLF2) expression
11257101This inappropriate deacetylation by HDAC4, HDAC5 and HDAC6 follows their relocalization from the cytoplasm to the nucleus
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