HCSGD entry for HDAC5
1. General information
Official gene symbol | HDAC5 |
---|---|
Entrez ID | 10014 |
Gene full name | histone deacetylase 5 |
Other gene symbols | HD5 NY-CO-9 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000118 | Histone deacetylase complex | TAS | cellular_component |
GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA IEA IMP | biological_process |
GO:0002076 | Osteoblast development | IEA | biological_process |
GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
GO:0004407 | Histone deacetylase activity | IDA | molecular_function |
GO:0005080 | Protein kinase C binding | IPI | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005634 | Nucleus | IDA | cellular_component |
GO:0005654 | Nucleoplasm | TAS | cellular_component |
GO:0005730 | Nucleolus | IDA | cellular_component |
GO:0005737 | Cytoplasm | IDA | cellular_component |
GO:0005794 | Golgi apparatus | IDA | cellular_component |
GO:0005829 | Cytosol | IEA | cellular_component |
GO:0006325 | Chromatin organization | TAS | biological_process |
GO:0006338 | Chromatin remodeling | TAS | biological_process |
GO:0006342 | Chromatin silencing | TAS | biological_process |
GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
GO:0006954 | Inflammatory response | TAS | biological_process |
GO:0007219 | Notch signaling pathway | TAS | biological_process |
GO:0007507 | Heart development | IEA | biological_process |
GO:0008134 | Transcription factor binding | IPI | molecular_function |
GO:0010830 | Regulation of myotube differentiation | ISS | biological_process |
GO:0010832 | Negative regulation of myotube differentiation | IMP | biological_process |
GO:0016568 | Chromatin modification | TAS | biological_process |
GO:0016575 | Histone deacetylation | IDA | biological_process |
GO:0016604 | Nuclear body | IEA | cellular_component |
GO:0030183 | B cell differentiation | TAS | biological_process |
GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | IEA | molecular_function |
GO:0032869 | Cellular response to insulin stimulus | NAS | biological_process |
GO:0033555 | Multicellular organismal response to stress | IEA | biological_process |
GO:0042113 | B cell activation | TAS | biological_process |
GO:0042220 | Response to cocaine | IEA | biological_process |
GO:0042493 | Response to drug | IEA | biological_process |
GO:0043234 | Protein complex | IEA | cellular_component |
GO:0043393 | Regulation of protein binding | IMP | biological_process |
GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
GO:0045668 | Negative regulation of osteoblast differentiation | IEA | biological_process |
GO:0045892 | Negative regulation of transcription, DNA-templated | TAS | biological_process |
GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
GO:0046872 | Metal ion binding | IEA | molecular_function |
GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) | IEA | molecular_function |
GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific) | IEA | molecular_function |
GO:0048742 | Regulation of skeletal muscle fiber development | IEA | biological_process |
GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IMP | biological_process |
GO:0070491 | Repressing transcription factor binding | IPI | molecular_function |
GO:0090051 | Negative regulation of cell migration involved in sprouting angiogenesis | IMP | biological_process |
GO:0097372 | NAD-dependent histone deacetylase activity (H3-K18 specific) | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.9320764523 | 0.0137883021 | 0.9999902473 | 0.2313217336 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.2855734706 |
GSE13712_SHEAR | Down | -0.6337212393 |
GSE13712_STATIC | Down | -0.7548902229 |
GSE19018 | Up | 0.1202442295 |
GSE19899_A1 | Down | -0.5236399417 |
GSE19899_A2 | Down | -0.8263422153 |
PubMed_21979375_A1 | Down | -1.3178637368 |
PubMed_21979375_A2 | Down | -0.5827781936 |
GSE35957 | Up | 0.5465042853 |
GSE36640 | Down | -0.1491003811 |
GSE54402 | Down | -0.0168093437 |
GSE9593 | Up | 0.0460747508 |
GSE43922 | Down | -0.7874517580 |
GSE24585 | Up | 0.3986826221 |
GSE37065 | Down | -0.2085247573 |
GSE28863_A1 | Up | 0.1036734568 |
GSE28863_A2 | Down | -0.2156474564 |
GSE28863_A3 | Down | -0.3693029573 |
GSE28863_A4 | Down | -0.1793917802 |
GSE48662 | Up | 0.5813447230 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
Panobinostat | DB06603 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-26b-5p | MIMAT0000083 | MIRT029704 | Microarray | Functional MTI (Weak) | 19088304 |
hsa-let-7a-5p | MIMAT0000062 | MIRT052514 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
26443543 | Similarly, two stilbenes also stimulated LKB1, AMPKalpha, extracellular-signal related kinase 5 (ERK5) phosphorylation, and histone acetylase 5 (HDAC5) and Kruppel-like factor 2 (KLF2) expression |
11257101 | This inappropriate deacetylation by HDAC4, HDAC5 and HDAC6 follows their relocalization from the cytoplasm to the nucleus |
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