HCSGD entry for PDCD6

1. General information

Official gene symbolPDCD6
Entrez ID10016
Gene full nameprogrammed cell death 6
Other gene symbolsALG-2 PEF1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0005509Calcium ion bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0006886Intracellular protein transportIDAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0010595Positive regulation of endothelial cell migrationIDAbiological_process
GO:0030948Negative regulation of vascular endothelial growth factor receptor signaling pathwayIDAbiological_process
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0031965Nuclear membraneIEAcellular_component
GO:0032007Negative regulation of TOR signalingIDAbiological_process
GO:0034605Cellular response to heatIDAbiological_process
GO:0036324Vascular endothelial growth factor receptor-2 signaling pathwayIDAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0046983Protein dimerization activityIPImolecular_function
GO:0048306Calcium-dependent protein bindingIEA IPImolecular_function
GO:0051592Response to calcium ionIEA ISSbiological_process
GO:0051898Negative regulation of protein kinase B signalingIDAbiological_process
GO:0060090Binding, bridgingIMPmolecular_function
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19753492270.95347305950.85910718771.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1175664170
GSE13712_SHEARUp0.1358546025
GSE13712_STATICUp0.1116396515
GSE19018Down-0.0732653668
GSE19899_A1Up0.2514712535
GSE19899_A2Up0.2650426175
PubMed_21979375_A1Down-0.1632385882
PubMed_21979375_A2Up0.3568713317
GSE35957Down-0.2142487877
GSE36640Up0.2142705319
GSE54402Up0.3069810868
GSE9593Down-0.0413528882
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.2167867320
GSE28863_A2Up0.3513293785
GSE28863_A3Up0.0373796013
GSE28863_A4Down-0.1264621968
GSE48662Down-0.0403336189

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-183-5pMIMAT0000261MIRT005725qRT-PCRNon-Functional MTI (Weak)20602797
hsa-miR-18a-3pMIMAT0002891MIRT040945CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21784712Important findings included significant upregulation of p53 and several proapoptotic genes (including apoptosis-inducing factor, mitochondrion-associated 1, BCL2-like 11 [an apoptosis facilitator]; caspase 7 apoptosis-related cysteine peptidase; proteasome 26S subunit nonadenosine triphosphatase 10, programmed cell death 6, and reticulon 3)
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