HCSGD entry for TOM1
1. General information
| Official gene symbol | TOM1 |
|---|---|
| Entrez ID | 10043 |
| Gene full name | target of myb1 (chicken) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0006897 | Endocytosis | NAS | biological_process |
| GO:0015031 | Protein transport | NAS | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016197 | Endosomal transport | NAS TAS | biological_process |
| GO:0030276 | Clathrin binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0071365184 | 0.9684682307 | 0.2207289072 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3113054675 |
| GSE13712_SHEAR | Down | -0.6704394915 |
| GSE13712_STATIC | Down | -0.2350869088 |
| GSE19018 | Up | 0.0549340845 |
| GSE19899_A1 | Up | 0.0432267052 |
| GSE19899_A2 | Up | 1.0064842365 |
| PubMed_21979375_A1 | Up | 2.1829994554 |
| PubMed_21979375_A2 | Up | 1.6050094216 |
| GSE35957 | Up | 0.3153330824 |
| GSE36640 | Up | 0.3959605935 |
| GSE54402 | Up | 0.7719973192 |
| GSE9593 | Up | 0.4882264430 |
| GSE43922 | Up | 0.2879905267 |
| GSE24585 | Up | 0.5663334539 |
| GSE37065 | Down | -0.0021520082 |
| GSE28863_A1 | Up | 0.2996525564 |
| GSE28863_A2 | Up | 0.0232275806 |
| GSE28863_A3 | Down | -0.1015147860 |
| GSE28863_A4 | Down | -0.0837638482 |
| GSE48662 | Up | 0.2817639999 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-126-3p | MIMAT0000445 | MIRT000967 | Luciferase reporter assay | Non-Functional MTI | 18834857 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT000967 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot | Functional MTI | 20083669 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028407 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046596 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-126-3p | MIMAT0000445 | NA | hsa-miR-126 | {Western blot} | {overexpression by miRNA precursor transfection} | 20083669 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15265694 | In addition, the expression of the gene TOM1 (target of Myb 1), which has not previously been associated with cellular senescence, is shown to increase in senescent cells, and we demonstrate that the expression of antisense TOM1 gene in 2BS cells can delay the progress of senescence |
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