HCSGD entry for UBA2
1. General information
| Official gene symbol | UBA2 |
|---|---|
| Entrez ID | 10054 |
| Gene full name | ubiquitin-like modifier activating enzyme 2 |
| Other gene symbols | ARX SAE2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006464 | Cellular protein modification process | IEA | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0008641 | Small protein activating enzyme activity | IEA | molecular_function |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0016925 | Protein sumoylation | IDA IEA TAS | biological_process |
| GO:0019948 | SUMO activating enzyme activity | IDA TAS | molecular_function |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0904406444 | 0.3487585502 | 0.6328641795 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0689342155 |
| GSE13712_SHEAR | Up | 0.0134417748 |
| GSE13712_STATIC | Up | 0.1129900045 |
| GSE19018 | Down | -0.4061731278 |
| GSE19899_A1 | Up | 0.2213246088 |
| GSE19899_A2 | Up | 0.3439017993 |
| PubMed_21979375_A1 | Up | 1.3488772384 |
| PubMed_21979375_A2 | Up | 0.4071952345 |
| GSE35957 | Up | 0.0968775644 |
| GSE36640 | Down | -0.8315021331 |
| GSE54402 | Up | 0.4305358683 |
| GSE9593 | Down | -0.1843416398 |
| GSE43922 | Up | 0.0601474686 |
| GSE24585 | Up | 0.0077399300 |
| GSE37065 | Down | -0.0091534906 |
| GSE28863_A1 | Down | -0.0364434791 |
| GSE28863_A2 | Down | -0.7667376373 |
| GSE28863_A3 | Up | 0.5585988650 |
| GSE28863_A4 | Up | 0.2429742328 |
| GSE48662 | Down | -0.2840000515 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020821 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-941 | MIMAT0004984 | MIRT036571 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-330-5p | MIMAT0004693 | MIRT038231 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038749 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042245 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047313 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047397 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048403 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048652 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050074 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26826302 | DESIGN: Expression of small ubiquitin-like modifier (SUMO) molecules, SUMO E1 activating enzymes SAE1 and SAE2, SUMO E2 conjugating enzyme UBC9, and de-sumoylation enzyme sentrin/SUMO-specific proteases (SENP)1 was immunolocalized in rat intervertebral disc (IVD) cells |
| 26826302 | In NP cells hypoxia transiently increased the expression of SUMO-1, SUMO-2/3, SAE2, and UBC9, whereas SUMO-1 was elevated while SUMO-2/3, SAE1, SAE2, and UBC9 were reduced by low oxygen tensions in AF cells |
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