HCSGD entry for SAE1
1. General information
| Official gene symbol | SAE1 |
|---|---|
| Entrez ID | 10055 |
| Gene full name | SUMO1 activating enzyme subunit 1 |
| Other gene symbols | AOS1 HSPC140 SUA1 UBLE1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004839 | Ubiquitin activating enzyme activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006464 | Cellular protein modification process | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IDA | molecular_function |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008641 | Small protein activating enzyme activity | IEA | molecular_function |
| GO:0016567 | Protein ubiquitination | TAS | biological_process |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0016925 | Protein sumoylation | IDA IEA TAS | biological_process |
| GO:0019948 | SUMO activating enzyme activity | IDA | molecular_function |
| GO:0043008 | ATP-dependent protein binding | IDA | molecular_function |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046982 | Protein heterodimerization activity | IPI TAS | molecular_function |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9735177995 | 0.0334531591 | 0.9999902473 | 0.3456141961 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1419129126 |
| GSE13712_SHEAR | Down | -0.0970015207 |
| GSE13712_STATIC | Down | -0.1307628121 |
| GSE19018 | Down | -0.2913949375 |
| GSE19899_A1 | Down | -0.5170434120 |
| GSE19899_A2 | Down | -0.3138117664 |
| PubMed_21979375_A1 | Down | -0.1483246907 |
| PubMed_21979375_A2 | Down | -1.1409132108 |
| GSE35957 | Down | -0.5127296656 |
| GSE36640 | Down | -0.7000786087 |
| GSE54402 | Up | 0.0693211700 |
| GSE9593 | Up | 0.1882917450 |
| GSE43922 | Down | -0.2346962156 |
| GSE24585 | Up | 0.0469117241 |
| GSE37065 | Down | -0.3984471921 |
| GSE28863_A1 | Down | -0.1016039929 |
| GSE28863_A2 | Down | -0.2193263618 |
| GSE28863_A3 | Up | 0.0249405729 |
| GSE28863_A4 | Up | 0.1083865467 |
| GSE48662 | Down | -0.2395171844 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036348 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040267 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042940 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT043603 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26826302 | DESIGN: Expression of small ubiquitin-like modifier (SUMO) molecules, SUMO E1 activating enzymes SAE1 and SAE2, SUMO E2 conjugating enzyme UBC9, and de-sumoylation enzyme sentrin/SUMO-specific proteases (SENP)1 was immunolocalized in rat intervertebral disc (IVD) cells |
| 26826302 | In NP cells hypoxia transiently increased the expression of SUMO-1, SUMO-2/3, SAE2, and UBC9, whereas SUMO-1 was elevated while SUMO-2/3, SAE1, SAE2, and UBC9 were reduced by low oxygen tensions in AF cells |
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