HCSGD entry for DNM1L

1. General information

Official gene symbolDNM1L
Entrez ID10059
Gene full namedynamin 1-like
Other gene symbolsDLP1 DRP1 DVLP DYMPLE EMPF HDYNIV
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000266Mitochondrial fissionIDA IMPbiological_process
GO:0001836Release of cytochrome c from mitochondriaIMPbiological_process
GO:0003374Dynamin polymerization involved in mitochondrial fissionIDAbiological_process
GO:0003924GTPase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005741Mitochondrial outer membraneIDA TAScellular_component
GO:0005777PeroxisomeIDA IMPcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006184GTP catabolic processIDAbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0010821Regulation of mitochondrion organizationIMPbiological_process
GO:0016559Peroxisome fissionIDA IMPbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030672Synaptic vesicle membraneIEAcellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032459Regulation of protein oligomerizationIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043653Mitochondrial fragmentation involved in apoptotic processIMPbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050714Positive regulation of protein secretionIDAbiological_process
GO:0051289Protein homotetramerizationIDAbiological_process
GO:0061025Membrane fusionIDAbiological_process
GO:0070266Necroptotic processIMPbiological_process
GO:0070584Mitochondrion morphogenesisIMPbiological_process
GO:0090141Positive regulation of mitochondrial fissionTASbiological_process
GO:0090149Membrane fission involved in mitochondrial fissionIDAbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIMPbiological_process
GO:1900063Regulation of peroxisome organizationIMPbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92718302500.26489674020.99999024730.9867933362

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0329147333
GSE13712_SHEARDown-0.1085868948
GSE13712_STATICUp0.0229624188
GSE19018Up0.1255046666
GSE19899_A1Up0.0030649395
GSE19899_A2Up0.0214523742
PubMed_21979375_A1Up0.1305845894
PubMed_21979375_A2Up0.1078510509
GSE35957Up0.0511970673
GSE36640Down-0.3475043241
GSE54402Up0.1442258737
GSE9593Down-0.1006510716
GSE43922Down-0.0910980071
GSE24585Down-0.0675423304
GSE37065Down-0.0253324151
GSE28863_A1Down-0.2345621135
GSE28863_A2Up0.0158351524
GSE28863_A3Down-0.8143408451
GSE28863_A4Up0.1650286527
GSE48662Down-0.2337671834

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT039911CLASHFunctional MTI (Weak)23622248
hsa-miR-25-3pMIMAT0000081MIRT050255CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20812868Additionally, in models of Alzheimer's disease, excessive NO generation leads to the formation of S-nitrosylated dynamin-related protein 1 (forming SNO-Drp1), which contributes to abnormal mitochondrial fragmentation and resultant synaptic damage
20103533Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1
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