HCSGD entry for PTPRU

1. General information

Official gene symbolPTPRU
Entrez ID10076
Gene full nameprotein tyrosine phosphatase, receptor type, U
Other gene symbolsFMI PCP-2 PTP PTP-J PTP-PI PTP-RO PTPPSI PTPRO PTPU2 R-PTP-PSI R-PTP-U hPTP-J
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004725Protein tyrosine phosphatase activityIDA IEA IMPmolecular_function
GO:0005001Transmembrane receptor protein tyrosine phosphatase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0006470Protein dephosphorylationIDAbiological_process
GO:0007155Cell adhesionNASbiological_process
GO:0007185Transmembrane receptor protein tyrosine phosphatase signaling pathwayNASbiological_process
GO:0008013Beta-catenin bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016337Cell-cell adhesionIDAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0034109Homotypic cell-cell adhesionIEAbiological_process
GO:0034394Protein localization to cell surfaceIDAbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIDA IMP NASbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03605106950.28429596520.43165363311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1022110752
GSE13712_SHEARDown-0.3225598158
GSE13712_STATICDown-0.3185344269
GSE19018Up0.0416185602
GSE19899_A1Up0.0595435999
GSE19899_A2Up0.7235738148
PubMed_21979375_A1Up0.5047809797
PubMed_21979375_A2Up0.1400672659
GSE35957Down-0.0689808294
GSE36640Down-0.2463466523
GSE54402Up0.6171540181
GSE9593Down-0.8097597725
GSE43922Up1.1792230418
GSE24585Down-0.3694931554
GSE37065Down-0.2136116683
GSE28863_A1Up0.6958565743
GSE28863_A2Up0.4147935601
GSE28863_A3Up0.2988503359
GSE28863_A4Down-0.2872044132
GSE48662Up0.8535317626

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019113MicroarrayFunctional MTI (Weak)18185580
hsa-miR-615-3pMIMAT0003283MIRT040396CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.