HCSGD entry for PDIA6
1. General information
| Official gene symbol | PDIA6 |
|---|---|
| Entrez ID | 10130 |
| Gene full name | protein disulfide isomerase family A, member 6 |
| Other gene symbols | ERP5 P5 TXNDC7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003756 | Protein disulfide isomerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006662 | Glycerol ether metabolic process | IEA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0015035 | Protein disulfide oxidoreductase activity | IEA | molecular_function |
| GO:0016853 | Isomerase activity | IEA | molecular_function |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9733491661 | 0.0254336119 | 0.9999902473 | 0.3063789931 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0814415732 |
| GSE13712_SHEAR | Up | 0.0375670526 |
| GSE13712_STATIC | Down | -0.0294258217 |
| GSE19018 | Up | 0.1493306328 |
| GSE19899_A1 | Down | -0.4948272599 |
| GSE19899_A2 | Down | -0.4472795909 |
| PubMed_21979375_A1 | Down | -0.7990107535 |
| PubMed_21979375_A2 | Down | -0.8325110041 |
| GSE35957 | Down | -0.7309053289 |
| GSE36640 | Down | -0.1671183056 |
| GSE54402 | Down | -0.0289838148 |
| GSE9593 | Down | -0.1430281784 |
| GSE43922 | Down | -0.1770444201 |
| GSE24585 | Down | -0.3320815157 |
| GSE37065 | Up | 0.1471147347 |
| GSE28863_A1 | Down | -0.0149730110 |
| GSE28863_A2 | Up | 0.5058062506 |
| GSE28863_A3 | Down | -0.2694597022 |
| GSE28863_A4 | Down | -0.1917808417 |
| GSE48662 | Down | -0.6030101714 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031810 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1909-3p | MIMAT0007883 | MIRT035802 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1304-5p | MIMAT0005892 | MIRT035870 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23466301 | These genes, PDIA3, WDR1, FSTL1, COPG1, LMAN1, and PDIA6, significantly downregulated |
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