HCSGD entry for CDK9

1. General information

Official gene symbolCDK9
Entrez ID1025
Gene full namecyclin-dependent kinase 9
Other gene symbolsC-2k CDC2L4 CTK1 PITALRE TAK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIDAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0004672Protein kinase activityTASmolecular_function
GO:0004693Cyclin-dependent protein serine/threonine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006282Regulation of DNA repairIDAbiological_process
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007049Cell cycleTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0008023Transcription elongation factor complexTAScellular_component
GO:0008024Positive transcription elongation factor complex bIDAcellular_component
GO:0008283Cell proliferationTASbiological_process
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0017069SnRNA bindingIEAmolecular_function
GO:0031056Regulation of histone modificationIDAbiological_process
GO:0043111Replication fork arrestIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0050434Positive regulation of viral transcriptionTASbiological_process
GO:0071157Negative regulation of cell cycle arrestIDAbiological_process
GO:0071345Cellular response to cytokine stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14212013220.97404875570.75692917851.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0982068642
GSE13712_SHEARUp0.2341214725
GSE13712_STATICUp0.2679589741
GSE19018Down-0.0161077052
GSE19899_A1Up0.0040696221
GSE19899_A2Up0.1940793269
PubMed_21979375_A1Up0.4036717829
PubMed_21979375_A2Down-0.3270702853
GSE35957Up0.0867674806
GSE36640Up0.0670241121
GSE54402Up0.3575395546
GSE9593Up0.1061776668
GSE43922Up0.1117030467
GSE24585Down-0.0491994312
GSE37065Down-0.0204023502
GSE28863_A1Up0.3512757253
GSE28863_A2Up0.2004713455
GSE28863_A3Up0.3103179423
GSE28863_A4Up0.1048791007
GSE48662Up0.0189493047

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

FlavopiridolDB03496 EXPT00998

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT000389ProteomicsFunctional MTI (Weak)18668040
hsa-miR-16-5pMIMAT0000069MIRT031696ProteomicsFunctional MTI (Weak)18668040
hsa-miR-193b-3pMIMAT0002819MIRT041575CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049212CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.