HCSGD entry for FSTL3

1. General information

Official gene symbolFSTL3
Entrez ID10272
Gene full namefollistatin-like 3 (secreted glycoprotein)
Other gene symbolsFLRG FSRP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001968Fibronectin bindingIPImolecular_function
GO:0002244Hematopoietic progenitor cell differentiationIDAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0022409Positive regulation of cell-cell adhesionIDAbiological_process
GO:0030141Secretory granuleIEAcellular_component
GO:0030324Lung developmentIEAbiological_process
GO:0030325Adrenal gland developmentIEAbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIDAbiological_process
GO:0032926Negative regulation of activin receptor signaling pathwayIDAbiological_process
GO:0044306Neuron projection terminusIEAcellular_component
GO:0045671Negative regulation of osteoclast differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048185Activin bindingIPImolecular_function
GO:0071248Cellular response to metal ionIEAbiological_process
GO:0090101Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18372032600.02365487630.83782385650.2967683508

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5933490370
GSE13712_SHEARUp1.3893077670
GSE13712_STATICUp1.4541013413
GSE19018Down-0.1583090899
GSE19899_A1Down-1.4813630552
GSE19899_A2Down-1.3015792463
PubMed_21979375_A1Down-0.7168582663
PubMed_21979375_A2Down-0.6711756650
GSE35957Up0.4178320138
GSE36640Up0.3506375405
GSE54402Down-0.1979150274
GSE9593Down-0.1811975872
GSE43922Down-0.6613379665
GSE24585Up0.2377460198
GSE37065Up0.0686648235
GSE28863_A1Up0.2974136820
GSE28863_A2Down-0.4297108539
GSE28863_A3Up0.0121499196
GSE28863_A4Up0.0156447014
GSE48662Up0.1926794895

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019986MicroarrayFunctional MTI (Weak)20215506
hsa-miR-9-5pMIMAT0000441MIRT021408MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT023194MicroarrayFunctional MTI (Weak)18668037
hsa-miR-122-5pMIMAT0000421MIRT023374MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.