HCSGD entry for ADAR
1. General information
| Official gene symbol | ADAR |
|---|---|
| Entrez ID | 103 |
| Gene full name | adenosine deaminase, RNA-specific |
| Other gene symbols | ADAR1 AGS6 DRADA DSH DSRAD G1P1 IFI-4 IFI4 K88DSRBP P136 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003726 | Double-stranded RNA adenosine deaminase activity | IDA IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA TAS | cellular_component |
| GO:0006382 | Adenosine to inosine editing | IDA IMP TAS | biological_process |
| GO:0006396 | RNA processing | IEA | biological_process |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0006606 | Protein import into nucleus | IDA | biological_process |
| GO:0006611 | Protein export from nucleus | IDA | biological_process |
| GO:0009615 | Response to virus | IMP | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016553 | Base conversion or substitution editing | IDA | biological_process |
| GO:0016556 | MRNA modification | TAS | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0031047 | Gene silencing by RNA | IEA | biological_process |
| GO:0035455 | Response to interferon-alpha | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0044387 | Negative regulation of protein kinase activity by regulation of protein phosphorylation | IDA IMP | biological_process |
| GO:0044530 | Supraspliceosomal complex | IDA | cellular_component |
| GO:0045070 | Positive regulation of viral genome replication | IDA IMP | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051607 | Defense response to virus | IEA | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0601926637 | 0.5506021656 | 0.5319943941 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5066239851 |
| GSE13712_SHEAR | Up | 0.5348698723 |
| GSE13712_STATIC | Up | 0.3931355028 |
| GSE19018 | Down | -0.0622237583 |
| GSE19899_A1 | Down | -0.1366588587 |
| GSE19899_A2 | Up | 0.1646183477 |
| PubMed_21979375_A1 | Up | 0.1521159622 |
| PubMed_21979375_A2 | Up | 0.7605876631 |
| GSE35957 | Down | -0.8410149749 |
| GSE36640 | Up | 0.3326183078 |
| GSE54402 | Up | 0.1327594449 |
| GSE9593 | Down | -0.0867507581 |
| GSE43922 | Up | 0.0289312659 |
| GSE24585 | Up | 0.2368353524 |
| GSE37065 | Up | 0.3034779612 |
| GSE28863_A1 | Up | 0.3602669160 |
| GSE28863_A2 | Up | 0.7638729744 |
| GSE28863_A3 | Down | -0.7723469445 |
| GSE28863_A4 | Down | -0.3654836112 |
| GSE48662 | Up | 0.1627723935 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002820 | Luciferase reporter assay//Microarray | Functional MTI | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002820 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT002820 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020248 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028111 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036504 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-625-5p | MIMAT0003294 | MIRT039595 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041936 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048109 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23209284 | ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells |
| 23209284 | The ADAR1 (adenosine deaminase acting on RNA1) gene was overexpressed in Bcl6-deficient cells, and its promoter analysis revealed that ADAR1 is a molecular target of Bcl6 |
| 23209284 | Exogenous ADAR1 induced adenosine-targeted DNA mutations in IgM B cells from ADAR1-transgenic mice and in wild-type mouse embryonic fibroblasts (MEFs) |
| 23209284 | These mutations accumulated in senescent MEFs accompanied with endogenous ADAR1 expression, and the frequency in senescent Bcl6-deficient MEFs was higher than senescent wild-type MEFs |
| 23209284 | Thus, Bcl6 protects senescent cells from accumulation of adenosine-targeted DNA mutations induced by ADAR1 |
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