HCSGD entry for TUBB4A

1. General information

Official gene symbolTUBB4A
Entrez ID10382
Gene full nametubulin, beta 4A class IVa
Other gene symbolsTUBB4 TUBB5 beta-5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000242Pericentriolar materialIEAcellular_component
GO:0000278Mitotic cell cycleTASbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0005200Structural constituent of cytoskeletonIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIDA IEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005929CiliumIEAcellular_component
GO:0006457Protein foldingTASbiological_process
GO:0007017Microtubule-based processIEAbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0033269Internode region of axonIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043209Myelin sheathIEAcellular_component
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0051258Protein polymerizationIEAbiological_process
GO:0051297Centrosome organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15295421530.94179190000.77985008721.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1304349081
GSE13712_SHEARUp0.3188167985
GSE13712_STATICUp0.0358395298
GSE19018Up0.0552639450
GSE19899_A1Up0.0045700210
GSE19899_A2Up0.3162182313
PubMed_21979375_A1Down-0.1301967120
PubMed_21979375_A2Up0.0212464138
GSE35957Up0.1749507152
GSE36640Up0.2168195366
GSE54402Up0.7683136676
GSE9593Up0.0639688532
GSE43922Up0.0360604999
GSE24585Up0.0431869543
GSE37065Down-0.0802546078
GSE28863_A1Down-0.0740070294
GSE28863_A2Down-0.0736510829
GSE28863_A3Up0.4449060453
GSE28863_A4Up0.0733992073
GSE48662Down-0.2248597733

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Epothilone DDB01873 EXPT01350
Epothilone BDB03010 EXPT01349
CYT997DB05147 -
ZEN-012DB06042 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022751MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1226-3pMIMAT0005577MIRT036536CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

12736271Stable overexpression of beta1 and beta5 subunits in WI38 established cell lines was shown to induce elevated expression levels of beta1 subunit in beta5 transfectants and vice versa
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