HCSGD entry for TUBB4B
1. General information
| Official gene symbol | TUBB4B |
|---|---|
| Entrez ID | 10383 |
| Gene full name | tubulin, beta 4B class IVb |
| Other gene symbols | Beta2 TUBB2 TUBB2C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0042267 | Natural killer cell mediated cytotoxicity | NAS | biological_process |
| GO:0042288 | MHC class I protein binding | TAS | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051082 | Unfolded protein binding | NAS | molecular_function |
| GO:0051084 | 'de novo' posttranslational protein folding | TAS | biological_process |
| GO:0051225 | Spindle assembly | IEA | biological_process |
| GO:0051258 | Protein polymerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9785357129 | 0.0195785570 | 0.9999902473 | 0.2729487288 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2089479807 |
| GSE13712_SHEAR | Down | -0.0770892384 |
| GSE13712_STATIC | Up | 0.0532701722 |
| GSE19018 | Down | -0.1553090339 |
| GSE19899_A1 | Down | -0.3958055429 |
| GSE19899_A2 | Down | -0.0979296200 |
| PubMed_21979375_A1 | Up | 0.4201489404 |
| PubMed_21979375_A2 | Down | -0.5032246402 |
| GSE35957 | Down | -1.2836573027 |
| GSE36640 | Down | -0.7380913296 |
| GSE54402 | Up | 0.0267476303 |
| GSE9593 | Down | -0.6124699101 |
| GSE43922 | Up | 0.0265885776 |
| GSE24585 | Up | 0.0428031779 |
| GSE37065 | Down | -0.1583967914 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.7864261665 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Mebendazole | DB00643 | APRD01086 |
| Epothilone D | DB01873 | EXPT01350 |
| Epothilone B | DB03010 | EXPT01349 |
| CYT997 | DB05147 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT007296 | Western blot | Functional MTI | 23338554 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031472 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036534 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043536 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044022 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-301a-3p | MIMAT0000688 | MIRT044225 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044273 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044989 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT045881 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049307 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050330 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050785 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050955 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051633 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
