HCSGD entry for MCRS1
1. General information
| Official gene symbol | MCRS1 |
|---|---|
| Entrez ID | 10445 |
| Gene full name | microspherule protein 1 |
| Other gene symbols | ICP22BP INO80Q MCRS2 MSP58 P78 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000123 | Histone acetyltransferase complex | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0031011 | Ino80 complex | IDA | cellular_component |
| GO:0043981 | Histone H4-K5 acetylation | IDA | biological_process |
| GO:0043982 | Histone H4-K8 acetylation | IDA | biological_process |
| GO:0043984 | Histone H4-K16 acetylation | IDA | biological_process |
| GO:0043995 | Histone acetyltransferase activity (H4-K5 specific) | IDA | molecular_function |
| GO:0043996 | Histone acetyltransferase activity (H4-K8 specific) | IDA | molecular_function |
| GO:0046972 | Histone acetyltransferase activity (H4-K16 specific) | IDA | molecular_function |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8790421489 | 0.0414560351 | 0.9999902473 | 0.3832915028 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0033076634 |
| GSE13712_SHEAR | Up | 0.0195499662 |
| GSE13712_STATIC | Up | 0.1139940323 |
| GSE19018 | Down | -0.1414610065 |
| GSE19899_A1 | Down | -0.5435126193 |
| GSE19899_A2 | Down | -0.0715406510 |
| PubMed_21979375_A1 | Up | 0.4583062369 |
| PubMed_21979375_A2 | Up | 0.5482985776 |
| GSE35957 | Down | -0.3655979580 |
| GSE36640 | Down | -0.7978426621 |
| GSE54402 | Up | 0.2000813088 |
| GSE9593 | Down | -0.3247536022 |
| GSE43922 | Down | -0.0063434913 |
| GSE24585 | Down | -0.6045948858 |
| GSE37065 | Down | -0.1483321203 |
| GSE28863_A1 | Down | -0.0786476408 |
| GSE28863_A2 | Down | -0.3196710669 |
| GSE28863_A3 | Down | -0.6401392031 |
| GSE28863_A4 | Up | 0.1030011939 |
| GSE48662 | Down | -0.0193021570 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041247 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT043001 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044730 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24361335 | The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF) |
| 24361335 | 58-kDa microspherule protein (MSP58) plays an important role in a variety of cellular processes including transcriptional regulation, cell proliferation and oncogenic transformation |
| 24361335 | Currently, the mechanisms underlying the oncogenic effect of MSP58 are not fully understood |
| 24361335 | Here we identify telomerase transcriptional element-interacting factor (TEIF) as a novel MSP58-interacting protein and determine the effect of MSP58 on hTERT transcription |
| 24361335 | This study thus provides evidence showing MSP58 to be a negative regulator of hTERT expression and telomerase activity |
| 24361335 | Luciferase reporter assays indicated that MSP58 could suppress the transcription ofhTERTpromoter |
| 24361335 | Additionally, stable overexpression of MSP58 protein in HT1080 and 293T cells decreased both endogenous hTERT expression and telomerase activity |
| 24361335 | Conversely, their upregulation was induced by MSP58 silencing |
| 24361335 | Chromatin immunoprecipitation assays showed that MSP58 binds to the hTERT proximal promoter |
| 24361335 | The inhibitory effect of MSP58 occurred through inhibition of TEIF binding to DNA |
| 24361335 | Together, our findings provide new insights into both the biological function of MSP58 and the regulation of telomerase/hTERT expression |
| 22563078 | 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway |
| 22563078 | The nucleolar 58-kDa microspherule protein (MSP58) protein is a candidate oncogene implicated in modulating cellular proliferation and malignant transformation |
| 22563078 | In this study, we show that knocking down MSP58 expression caused aneuploidy and led to apoptosis, whereas ectopic expression of MSP58 regulated cell proliferation in a context-dependent manner |
| 22563078 | Specifically, ectopic expression of MSP58 in normal human IMR90 and Hs68 diploid fibroblasts, the H184B5F5/M10 mammary epithelial cell line, HT1080 fibrosarcoma cells, primary mouse embryonic fibroblasts, and immortalized NIH3T3 fibroblasts resulted in induction of premature senescence, an enlarged and flattened cellular morphology, and increased senescence-associated beta-galactosidase activity |
| 22563078 | At least two senescence mechanisms are induced by MSP58 |
| 22563078 | First, MSP58 activates the DNA damage response and p53/p21 signaling pathways |
| 22563078 | Second, MSP58, p53, and the SWI/SNF chromatin-remodeling subunit Brahma-related gene 1 (BRG1) form a ternary complex on the p21 promoter and collaborate to activate p21 |
| 22563078 | Additionally, MSP58 protein levels increased in cells undergoing replicative senescence and stress-induced senescence |
| 22563078 | Notably, the results of analyzing expression levels of MSP58 between tumors and matched normal tissues showed significant changes (both up- and down-regulation) in its expression in various types of tumors |
| 22563078 | Our findings highlight new aspects of MSP58 in modulating cellular senescence and suggest that MSP58 has both oncogenic and tumor-suppressive properties |
Entries Per Page
Displaying Page of
