HCSGD entry for FST
1. General information
| Official gene symbol | FST |
|---|---|
| Entrez ID | 10468 |
| Gene full name | follistatin |
| Other gene symbols | FS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0002244 | Hematopoietic progenitor cell differentiation | IDA | biological_process |
| GO:0004871 | Signal transducer activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007276 | Gamete generation | IEA | biological_process |
| GO:0007389 | Pattern specification process | IEA | biological_process |
| GO:0008585 | Female gonad development | IEA | biological_process |
| GO:0030509 | BMP signaling pathway | IEA | biological_process |
| GO:0031069 | Hair follicle morphogenesis | IEA | biological_process |
| GO:0032926 | Negative regulation of activin receptor signaling pathway | IDA | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0043395 | Heparan sulfate proteoglycan binding | IEA | molecular_function |
| GO:0043616 | Keratinocyte proliferation | IEA | biological_process |
| GO:0045596 | Negative regulation of cell differentiation | IEA | biological_process |
| GO:0048185 | Activin binding | IPI | molecular_function |
| GO:0051798 | Positive regulation of hair follicle development | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0677740283 | 0.0006350633 | 0.5596405897 | 0.0469536517 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8330430151 |
| GSE13712_SHEAR | Up | 0.8851994325 |
| GSE13712_STATIC | Up | 2.9875755920 |
| GSE19018 | Down | -0.3891958077 |
| GSE19899_A1 | Down | -1.3436893961 |
| GSE19899_A2 | Down | -2.8538767896 |
| PubMed_21979375_A1 | Down | -4.0372274029 |
| PubMed_21979375_A2 | Down | -5.3261767920 |
| GSE35957 | Up | 0.8441209092 |
| GSE36640 | Down | -1.3367198736 |
| GSE54402 | Down | -1.2776202713 |
| GSE9593 | Down | -0.3203401738 |
| GSE43922 | Down | -2.3463954862 |
| GSE24585 | Up | 0.3290985388 |
| GSE37065 | Up | 0.3599204921 |
| GSE28863_A1 | Down | -0.6661899045 |
| GSE28863_A2 | Up | 0.2623706665 |
| GSE28863_A3 | Up | 0.4497865804 |
| GSE28863_A4 | Up | 0.3439264346 |
| GSE48662 | Up | 0.5440560460 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| D-Myo-Inositol-Hexasulphate | DB01666 | EXPT01854 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10859029 | BACKGROUND: mac25 is a follistatin (FS)-like protein that has a growth-suppressing effect on a p53-deficient osteosarcoma cell line (Saos-2) |
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