HCSGD entry for CEBPG
1. General information
| Official gene symbol | CEBPG |
|---|---|
| Entrez ID | 1054 |
| Gene full name | CCAAT/enhancer binding protein (C/EBP), gamma |
| Other gene symbols | GPE1BP IG/EBP-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001889 | Liver development | IEA ISS | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0006955 | Immune response | ISS | biological_process |
| GO:0008134 | Transcription factor binding | IDA | molecular_function |
| GO:0016071 | MRNA metabolic process | IEA | biological_process |
| GO:0030183 | B cell differentiation | IEA ISS | biological_process |
| GO:0042267 | Natural killer cell mediated cytotoxicity | IEA ISS | biological_process |
| GO:0043353 | Enucleate erythrocyte differentiation | IEA ISS | biological_process |
| GO:0043388 | Positive regulation of DNA binding | TAS | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IEA ISS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA IEA | molecular_function |
| GO:0045078 | Positive regulation of interferon-gamma biosynthetic process | IEA ISS | biological_process |
| GO:0045739 | Positive regulation of DNA repair | IEP | biological_process |
| GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6165582539 | 0.0857439649 | 0.9999902473 | 0.5565639704 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3284144241 |
| GSE13712_SHEAR | Up | 0.4192015792 |
| GSE13712_STATIC | Down | -0.1088009039 |
| GSE19018 | Up | 0.4344797187 |
| GSE19899_A1 | Down | -0.3938667300 |
| GSE19899_A2 | Down | -0.1835416061 |
| PubMed_21979375_A1 | Up | 0.9548381639 |
| PubMed_21979375_A2 | Down | -0.4161624761 |
| GSE35957 | Down | -0.6474211651 |
| GSE36640 | Down | -0.9174632040 |
| GSE54402 | Up | 0.0259416123 |
| GSE9593 | Up | 0.0824133621 |
| GSE43922 | Up | 0.0494566714 |
| GSE24585 | Up | 0.0636082994 |
| GSE37065 | Down | -0.2236830316 |
| GSE28863_A1 | Down | -0.1806585990 |
| GSE28863_A2 | Down | -0.4061434338 |
| GSE28863_A3 | Up | 0.0284581371 |
| GSE28863_A4 | Up | 0.0107673864 |
| GSE48662 | Up | 0.4431483996 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | MIRT002387 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT020090 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028205 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039508 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045272 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23775115 | Cebpg(-/-) mouse embryonic fibroblasts (MEFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signature, including elevated levels of senescence-associated secretory phenotype (SASP) genes whose induction by oncogenic stress requires C/EBPbeta |
| 23775115 | C/EBPbeta depletion partially restored growth of C/EBPgamma-deficient cells, indicating that the increased levels of C/EBPbeta homodimers in Cebpg(-/-) MEFs inhibit proliferation |
| 23775115 | The proliferative functions of C/EBPgamma are not restricted to fibroblasts, as hematopoietic progenitors from Cebpg(-/-) bone marrow also displayed impaired growth |
| 23775115 | Furthermore, high CEBPG expression correlated with poorer clinical prognoses in several human cancers, and C/EBPgamma depletion decreased proliferation and induced senescence in lung tumor cells |
Entries Per Page
Displaying Page of
