HCSGD entry for LAMTOR5
1. General information
| Official gene symbol | LAMTOR5 |
|---|---|
| Entrez ID | 10542 |
| Gene full name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
| Other gene symbols | HBXIP XIP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0008361 | Regulation of cell size | IMP | biological_process |
| GO:0009615 | Response to virus | TAS | biological_process |
| GO:0019079 | Viral genome replication | IEA | biological_process |
| GO:0032008 | Positive regulation of TOR signaling | IMP | biological_process |
| GO:0032947 | Protein complex scaffold | IDA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IDA IEA | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IDA IEA | biological_process |
| GO:0061462 | Protein localization to lysosome | IMP | biological_process |
| GO:0071230 | Cellular response to amino acid stimulus | IMP | biological_process |
| GO:0071986 | Ragulator complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4895527488 | 0.5476833327 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2629975950 |
| GSE13712_SHEAR | Down | -0.2020494396 |
| GSE13712_STATIC | Down | -0.0485188009 |
| GSE19018 | Up | 0.4411682272 |
| GSE19899_A1 | Up | 0.2192967931 |
| GSE19899_A2 | Up | 0.1544534884 |
| PubMed_21979375_A1 | Down | -0.1724689106 |
| PubMed_21979375_A2 | Up | 0.2226389294 |
| GSE35957 | Down | -0.1883970980 |
| GSE36640 | Up | 0.0394563170 |
| GSE54402 | Up | 0.2060191924 |
| GSE9593 | Up | 0.0332534901 |
| GSE43922 | Down | -0.0182448453 |
| GSE24585 | Down | -0.2017953186 |
| GSE37065 | Down | -0.0675610799 |
| GSE28863_A1 | Down | -0.1954684971 |
| GSE28863_A2 | Up | 0.1181961109 |
| GSE28863_A3 | Down | -0.3677540620 |
| GSE28863_A4 | Down | -0.1609149821 |
| GSE48662 | Up | 0.1518860164 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001458 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-501-5p | MIMAT0002872 | MIRT007340 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23266610 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024286 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026572 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046932 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18158869 | Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells |
| 18158869 | AIM: We previously found that the hepatitis B X-interacting protein (HBXIP) was able to promote the proliferation of cells |
| 18158869 | To investigate the mechanism of promoting proliferation by HBXIP, the effect of HBXIP on human TERT (hTERT) was investigated in human mesenchymal stem cells (hMSC) |
| 18158869 | METHODS: BMMS-03 cells and hMSC from the bone marrow of a 4-month-old elicited fetus, were transiently transfected with the pcDNA3-hbxip plasmid encoding the HBXIP gene and pSilencer-hbxip plasmid encoding RNA interference (RNAi) targeting HBXIP mRNA, followed by the examination of the hTERT promoter reporter gene by luciferase assay, and the detection of telomerase activity by telomeric repeat amplication protocol, respectively, as well as the expression levels of hTERT, c-Myc, and Bcl-2 by Western blot analysis |
| 18158869 | RESULTS: The overexpression of HBXIP led to a significant upregulation of hTERT promoter activity, telomerase activity, and the expression levels of hTERT, c-Myc, and Bcl-2 in BMMS-03 cells |
| 18158869 | RNAi targeting HBXIP mRNA produced the opposite results completely |
| 18158869 | CONCLUSION: Our data demonstrated that HBXIP significantly stimulated the transcription and expression of hTERT and increased the activity of telomerase in BMMS-03 cells, which provides a new insight into the mechanism of promoting cell proliferation by HBXIP |
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