HCSGD entry for SH2B2

1. General information

Official gene symbolSH2B2
Entrez ID10603
Gene full nameSH2B adaptor protein 2
Other gene symbolsAPS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001725Stress fiberIEAcellular_component
GO:0001726RuffleIEAcellular_component
GO:0001922B-1 B cell homeostasisIEAbiological_process
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005068Transmembrane receptor protein tyrosine kinase adaptor activityIEAmolecular_function
GO:0005070SH3/SH2 adaptor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005884Actin filamentIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008269JAK pathway signal transduction adaptor activityIDAmolecular_function
GO:0008286Insulin receptor signaling pathwayIEA ISSbiological_process
GO:0009967Positive regulation of signal transductionIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0019222Regulation of metabolic processIEAbiological_process
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0035556Intracellular signal transductionIDA IEAbiological_process
GO:0042802Identical protein bindingIEAmolecular_function
GO:0046425Regulation of JAK-STAT cascadeIDAbiological_process
GO:0046578Regulation of Ras protein signal transductionIEAbiological_process
GO:0050851Antigen receptor-mediated signaling pathwayIEAbiological_process
GO:0050873Brown fat cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30424705370.53971194100.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1147772381
GSE13712_SHEARDown-0.5023136237
GSE13712_STATICUp0.2712849887
GSE19018Up0.2718574920
GSE19899_A1Down-0.0115041768
GSE19899_A2Up0.4633693965
PubMed_21979375_A1Up0.3108160945
PubMed_21979375_A2Up0.6753746766
GSE35957Down-0.4873587172
GSE36640Down-0.1478847605
GSE54402Up0.1530110861
GSE9593Down-0.4975944997
GSE43922Up0.0507981805
GSE24585Down-0.0701020506
GSE37065Up0.0152889727
GSE28863_A1Down-0.1588369482
GSE28863_A2Down-0.0023263665
GSE28863_A3Up0.3338514614
GSE28863_A4Down-0.0957122077
GSE48662Up0.3899742886

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.