HCSGD entry for CENPF
1. General information
| Official gene symbol | CENPF |
|---|---|
| Entrez ID | 1063 |
| Gene full name | centromere protein F, 350/400kDa |
| Other gene symbols | CENF PRO1779 hcp-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000085 | Mitotic G2 phase | IMP | biological_process |
| GO:0000087 | Mitotic M phase | IDA IMP | biological_process |
| GO:0000278 | Mitotic cell cycle | IMP TAS | biological_process |
| GO:0000775 | Chromosome, centromeric region | IDA | cellular_component |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000785 | Chromatin | NAS | cellular_component |
| GO:0000922 | Spindle pole | IDA | cellular_component |
| GO:0000940 | Condensed chromosome outer kinetochore | IDA TAS | cellular_component |
| GO:0003682 | Chromatin binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005635 | Nuclear envelope | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005819 | Spindle | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0007059 | Chromosome segregation | IMP NAS | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007094 | Mitotic spindle assembly checkpoint | NAS | biological_process |
| GO:0007517 | Muscle organ development | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008283 | Cell proliferation | NAS | biological_process |
| GO:0010389 | Regulation of G2/M transition of mitotic cell cycle | IMP | biological_process |
| GO:0015031 | Protein transport | IDA IMP | biological_process |
| GO:0016202 | Regulation of striated muscle tissue development | ISS | biological_process |
| GO:0016363 | Nuclear matrix | IDA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0042493 | Response to drug | NAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0045120 | Pronucleus | IEA | cellular_component |
| GO:0045502 | Dynein binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051310 | Metaphase plate congression | IDA | biological_process |
| GO:0051382 | Kinetochore assembly | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6418056305 | 0.0000314160 | 0.9999902473 | 0.0099166667 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9629266768 |
| GSE13712_SHEAR | Down | -0.4795846780 |
| GSE13712_STATIC | Down | -0.7469134896 |
| GSE19018 | Up | 0.2733334881 |
| GSE19899_A1 | Down | -1.2622378119 |
| GSE19899_A2 | Down | -3.1954632777 |
| PubMed_21979375_A1 | Down | -2.9667271141 |
| PubMed_21979375_A2 | Down | -3.9952351910 |
| GSE35957 | Down | -2.6871133824 |
| GSE36640 | Down | -3.7823533617 |
| GSE54402 | Down | -1.0613682371 |
| GSE9593 | Down | -1.0835295532 |
| GSE43922 | Down | -2.6273139660 |
| GSE24585 | Down | -0.2025071793 |
| GSE37065 | Down | -1.3397080205 |
| GSE28863_A1 | Up | 0.3475858119 |
| GSE28863_A2 | Up | 2.2126332624 |
| GSE28863_A3 | Up | 0.2313414153 |
| GSE28863_A4 | Up | 0.2205136287 |
| GSE48662 | Down | -1.7588711025 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT002525 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-375 | MIMAT0000728 | MIRT019840 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023287 | Proteomics | Functional MTI (Weak) | 21750653 |
| hsa-miR-1 | MIMAT0000416 | MIRT023780 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024521 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026480 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031672 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036512 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037353 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038774 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
