HCSGD entry for CAMKK2
1. General information
| Official gene symbol | CAMKK2 |
|---|---|
| Entrez ID | 10645 |
| Gene full name | calcium/calmodulin-dependent protein kinase kinase 2, beta |
| Other gene symbols | CAMKK CAMKKB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004683 | Calmodulin-dependent protein kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IDA | molecular_function |
| GO:0005516 | Calmodulin binding | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | TAS | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
| GO:0019722 | Calcium-mediated signaling | TAS | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0045859 | Regulation of protein kinase activity | TAS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2255392462 | 0.7648891835 | 0.9068772533 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0122325486 |
| GSE13712_SHEAR | Up | 0.0583423484 |
| GSE13712_STATIC | Down | -0.0549896592 |
| GSE19018 | Down | -0.0076086970 |
| GSE19899_A1 | Up | 0.0034182475 |
| GSE19899_A2 | Up | 0.3816441967 |
| PubMed_21979375_A1 | Up | 0.0302384106 |
| PubMed_21979375_A2 | Up | 0.0950717069 |
| GSE35957 | Down | -0.1177153203 |
| GSE36640 | Up | 0.1991534639 |
| GSE54402 | Down | -0.0104219623 |
| GSE9593 | Up | 0.2817423003 |
| GSE43922 | Up | 0.0487322584 |
| GSE24585 | Down | -0.4545693265 |
| GSE37065 | Down | -0.1972508487 |
| GSE28863_A1 | Up | 0.5590522171 |
| GSE28863_A2 | Up | 0.3138906519 |
| GSE28863_A3 | Down | -0.3053458541 |
| GSE28863_A4 | Up | 0.0295171663 |
| GSE48662 | Up | 0.6877762424 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027179 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031851 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045326 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048541 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
