HCSGD entry for CORIN
1. General information
| Official gene symbol | CORIN |
|---|---|
| Entrez ID | 10699 |
| Gene full name | corin, serine peptidase |
| Other gene symbols | ATC2 CRN Lrp4 PEE5 TMPRSS10 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003050 | Regulation of systemic arterial blood pressure by atrial natriuretic peptide | IEA IMP ISS | biological_process |
| GO:0004252 | Serine-type endopeptidase activity | IDA IEA | molecular_function |
| GO:0005044 | Scavenger receptor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007565 | Female pregnancy | IEA IMP | biological_process |
| GO:0008217 | Regulation of blood pressure | ISS | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016486 | Peptide hormone processing | IDA IEA | biological_process |
| GO:0035813 | Regulation of renal sodium excretion | IEA ISS | biological_process |
| GO:0070008 | Serine-type exopeptidase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9236214164 | 0.0044579613 | 0.9999902473 | 0.1354076037 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1274598709 |
| GSE13712_SHEAR | Up | 0.0766135009 |
| GSE13712_STATIC | Up | 0.0499461969 |
| GSE19018 | Down | -1.5988833622 |
| GSE19899_A1 | Down | -0.0438642696 |
| GSE19899_A2 | Down | -1.6503838625 |
| PubMed_21979375_A1 | Down | -1.8365485862 |
| PubMed_21979375_A2 | Down | -2.4003748000 |
| GSE35957 | Up | 0.2304109333 |
| GSE36640 | Down | -0.0428225586 |
| GSE54402 | Down | -2.0022524769 |
| GSE9593 | Down | -0.2510191891 |
| GSE43922 | Down | -1.6795344248 |
| GSE24585 | Down | -0.0693264156 |
| GSE37065 | Down | -0.0511148728 |
| GSE28863_A1 | Down | -0.0039209080 |
| GSE28863_A2 | Up | 0.0208807224 |
| GSE28863_A3 | Up | 0.0524368016 |
| GSE28863_A4 | Up | 0.0543981624 |
| GSE48662 | Up | 0.1755621672 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25543718 | Involvement of corin downregulation in ionizing radiation-induced senescence of myocardial cells |
| 25543718 | Notably, the expression of corin, a cardiac protease that is essential for the proteolytic cleavage of natriuretic peptides, was significantly decreased following the exposure of the cells to IR |
| 25543718 | Importantly, the knockdown of corin by RNA interference enhanced IR-induced senescence |
| 25543718 | Taken together, our data suggest that defects in corin function and the inhibition of natriuretic peptides following exposure to IR may contribute to the development of RIHD through the acceleration of cellular senescence |
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