HCSGD entry for CGA

1. General information

Official gene symbolCGA
Entrez ID1081
Gene full nameglycoprotein hormones, alpha polypeptide
Other gene symbolsCG-ALPHA FSHA GPHA1 GPHa HCG LHA TSHA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005179Hormone activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0006590Thyroid hormone generationIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008284Positive regulation of cell proliferationNASbiological_process
GO:0008406Gonad developmentIEAbiological_process
GO:0016486Peptide hormone processingTASbiological_process
GO:0030335Positive regulation of cell migrationNASbiological_process
GO:0030878Thyroid gland developmentIEAbiological_process
GO:0032275Luteinizing hormone secretionIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterNASbiological_process
GO:0046621Negative regulation of organ growthIEAbiological_process
GO:0046884Follicle-stimulating hormone secretionIEAbiological_process
GO:0048589Developmental growthIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82810526200.08435389230.99999024730.5515745220

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0158940951
GSE13712_SHEARDown-0.0234118224
GSE13712_STATICDown-0.0251881941
GSE19018Down-0.0429363193
GSE19899_A1Up0.0249057705
GSE19899_A2Up0.5073101520
PubMed_21979375_A1Up0.0625721744
PubMed_21979375_A2Down-0.3945880954
GSE35957Down-0.0570420018
GSE36640Down-0.4656413955
GSE54402Down-0.3748102868
GSE9593Up0.0872166990
GSE43922Up0.0766229697
GSE24585Down-2.1546353745
GSE37065Up0.0050843105
GSE28863_A1Up0.1341560335
GSE28863_A2Up0.2969069541
GSE28863_A3Up0.1306797834
GSE28863_A4Down-0.0268266235
GSE48662Down-0.0837091918

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018742MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23807740Further, no detailed study is available to suggest whether condurango-glycoside-A (CGA), a major ingredient of condurango serves as a potent anticancer compound
23807740Therefore, we investigated apoptosis-inducing ability of CGA against cervix carcinoma cells (HeLa)
23807740Overall results suggest that CGA initiates ROS generation, promoting up-regulation of p53 expression, thus resulting in apoptosis and pre-mature senescence associated with DNA damage
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