HCSGD entry for CYP46A1

1. General information

Official gene symbolCYP46A1
Entrez ID10858
Gene full namecytochrome P450, family 46, subfamily A, polypeptide 1
Other gene symbolsCP46 CYP46
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004497Monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005783Endoplasmic reticulumTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006699Bile acid biosynthetic processTASbiological_process
GO:0006707Cholesterol catabolic processIDAbiological_process
GO:0006805Xenobiotic metabolic processIDA TASbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008206Bile acid metabolic processTASbiological_process
GO:0008395Steroid hydroxylase activityTASmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016125Sterol metabolic processTASbiological_process
GO:0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEAmolecular_function
GO:0020037Heme bindingIDA IEAmolecular_function
GO:0033781Cholesterol 24-hydroxylase activityIDAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38076356520.91916670720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0712569322
GSE13712_SHEARDown-0.0859193043
GSE13712_STATICDown-0.0278585258
GSE19018Up0.2336064024
GSE19899_A1Down-0.0097508246
GSE19899_A2Down-0.2173078408
PubMed_21979375_A1Down-0.0584142414
PubMed_21979375_A2Down-0.0962238244
GSE35957Up0.1119297176
GSE36640Up0.1990128518
GSE54402Up0.0139349683
GSE9593Up0.2243990069
GSE43922Up0.0390548922
GSE24585Up0.2581765688
GSE37065Down-0.1179017402
GSE28863_A1Down-0.0770909046
GSE28863_A2Up0.0554096899
GSE28863_A3Up0.3954364946
GSE28863_A4Up0.0692772876
GSE48662Up0.2189870829

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.