HCSGD entry for ADAM28

1. General information

Official gene symbolADAM28
Entrez ID10863
Gene full nameADAM metallopeptidase domain 28
Other gene symbolsADAM 28 ADAM23 MDC-L MDC-Lm MDC-Ls MDCL eMDC II eMDCII
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004222Metalloendopeptidase activityIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEAbiological_process
GO:0007283SpermatogenesisTASbiological_process
GO:0008237Metallopeptidase activityIDAmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42147655860.77845463700.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0741281684
GSE13712_SHEARUp0.0865548788
GSE13712_STATICUp0.0471015823
GSE19018Up0.1174906449
GSE19899_A1Down-0.0257066660
GSE19899_A2Up0.0382640188
PubMed_21979375_A1Up0.1092036312
PubMed_21979375_A2Up0.0823366429
GSE35957Up0.0180514012
GSE36640Up0.4284220756
GSE54402Up0.2064008865
GSE9593Up0.0530972415
GSE43922Up0.0549520965
GSE24585Up0.3214617538
GSE37065Up0.1287742364
GSE28863_A1Down-0.4284641508
GSE28863_A2Up0.2132383977
GSE28863_A3Down-0.1603254451
GSE28863_A4Down-0.1660977635
GSE48662Up0.0106764301

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-[(Furan-2-Yl)Carbonyl]-(S)-Leucyl-(R)-[1-Amino-2(1h-Indol-3-Yl)Ethyl]-Phosphonic AcidDB02046 EXPT01449
Furoyl-LeucineDB02215 EXPT01441
GM6001DB02255 EXPT01618
2-(Thiomethylene)-4-Methylpentanoic AcidDB02996 EXPT02916
Pyroglutamic AcidDB03088 EXPT00247
BatimastatDB03880 EXPT00627
(2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDEDB08733 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.