HCSGD entry for TMED2
1. General information
| Official gene symbol | TMED2 |
|---|---|
| Entrez ID | 10959 |
| Gene full name | transmembrane emp24 domain trafficking protein 2 |
| Other gene symbols | P24A RNP24 p24 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001893 | Maternal placenta development | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005793 | Endoplasmic reticulum-Golgi intermediate compartment | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0006886 | Intracellular protein transport | IDA | biological_process |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0007030 | Golgi organization | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IEA ISS | cellular_component |
| GO:0030137 | COPI-coated vesicle | ISS | cellular_component |
| GO:0030663 | COPI-coated vesicle membrane | IEA | cellular_component |
| GO:0032580 | Golgi cisterna membrane | IEA | cellular_component |
| GO:0033116 | Endoplasmic reticulum-Golgi intermediate compartment membrane | IEA | cellular_component |
| GO:0034260 | Negative regulation of GTPase activity | IDA | biological_process |
| GO:0035459 | Cargo loading into vesicle | TAS | biological_process |
| GO:0042589 | Zymogen granule membrane | IEA ISS | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0048205 | COPI coating of Golgi vesicle | TAS | biological_process |
| GO:0048208 | COPII vesicle coating | TAS | biological_process |
| GO:0048598 | Embryonic morphogenesis | IEA | biological_process |
| GO:0072661 | Protein targeting to plasma membrane | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7664120056 | 0.3923067817 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2401835312 |
| GSE13712_SHEAR | Up | 0.1149334624 |
| GSE13712_STATIC | Up | 0.0016021634 |
| GSE19018 | Down | -0.1414317037 |
| GSE19899_A1 | Up | 0.0246660918 |
| GSE19899_A2 | Down | -0.1194096944 |
| PubMed_21979375_A1 | Up | 0.0864992109 |
| PubMed_21979375_A2 | Down | -0.3888716184 |
| GSE35957 | Down | -0.1341440205 |
| GSE36640 | Up | 0.1662953301 |
| GSE54402 | Down | -0.0528210634 |
| GSE9593 | Up | 0.2494226358 |
| GSE43922 | Up | 0.0156453797 |
| GSE24585 | Down | -0.2076102640 |
| GSE37065 | Up | 0.0951255821 |
| GSE28863_A1 | Down | -0.0592212919 |
| GSE28863_A2 | Up | 0.0662590467 |
| GSE28863_A3 | Down | -0.4125581171 |
| GSE28863_A4 | Up | 0.0515744529 |
| GSE48662 | Down | -0.2371952600 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005187 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016541 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039998 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT047764 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
