HCSGD entry for TLK2

1. General information

Official gene symbolTLK2
Entrez ID11011
Gene full nametousled-like kinase 2
Other gene symbolsHsHPK PKU-ALPHA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001672Regulation of chromatin assembly or disassemblyIDAbiological_process
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005882Intermediate filamentIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007059Chromosome segregationIMPbiological_process
GO:0010507Negative regulation of autophagyNASbiological_process
GO:0016568Chromatin modificationIEAbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0032435Negative regulation of proteasomal ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0071480Cellular response to gamma radiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85112752550.62748589340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0851479681
GSE13712_SHEARUp0.3470138659
GSE13712_STATICUp0.1487935409
GSE19018Down-0.2594534010
GSE19899_A1Down-0.0636445812
GSE19899_A2Down-0.1106651778
PubMed_21979375_A1Down-0.1136090856
PubMed_21979375_A2Up0.0026144371
GSE35957Down-0.0422438694
GSE36640Down-0.1754999238
GSE54402Up0.1305386498
GSE9593Up0.0610030700
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.1002090041
GSE28863_A2Down-0.0793713806
GSE28863_A3Down-0.1812878894
GSE28863_A4Down-0.0706766398
GSE48662Up0.1978079513

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-3pMIMAT0004509MIRT038762CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.